Comparative genetic analysis of different forms of low-renin arterial hypertension

N. M. Chikhladze, Kh F. Samedova, M. A. Sudomoina, Ko Min, Ju A. Koliadina, G. N. Litonova, Alexander Favorov, I. E. Chazova, O. O. Favorova

Research output: Contribution to journalArticle

Abstract

Arterial hypertension (AH) ranks among the most widespread cardiovascular diseases and is clinically and genetically heterogeneous. Except for rare monogenic forms, AH is polygenic, and an important role in AH predisposition belongs to genes of the renin-angiotensin-aldosterone system. Low renin activity in blood plasma is observed in 20-25% of AH cases (low-renin form of AH), while aldosterone production can be elevated (hyperaldosteronism, HA) or normal in these cases. Several polymorphisms of the genes coding for the renin-angiotensin-aldosterone system components were studied in patients with low-renin AH forms: primary HA, idiopathic HA, and AH with a normal aldosterone level. The chimeric CYP11B2/CYP11B1 gene, causing monogenic familial HA type 1, was absent from all HA cases studied. The patient groups were compared with respect to the allele and genotype frequency distributions of the polymorphisms of several genes (CYP11B2 (C-344T), REN (C-5434T, C-5312T, and A BglI G), AGT (Thr174Met), ACE (I/D), CMA (G-1903A), AT2R1 (A1166C)), and their combinations. Analysis of the carriership of the allele and genotype combinations implicated CYP11B2, REN, ACE, CMA, and AT2R1 in low-renin HA. The results revealed both similar and different features in the genetic nature of different low-renin AH forms. Investigation of the genetic predisposition to clinically heterogeneous forms of polygenic diseases by comparing patient groups, formed in accordance with peculiarities of the disease course, holds much promise for understanding their hereditary background.

Original languageEnglish (US)
Pages (from-to)521-530
Number of pages10
JournalMolecular Biology
Volume42
Issue number4
DOIs
StatePublished - Aug 2008

Fingerprint

Renin
Hyperaldosteronism
Hypertension
Cytochrome P-450 CYP11B2
Renin-Angiotensin System
Aldosterone
Genes
Steroid 11-beta-Hydroxylase
Genotype
Genetic Predisposition to Disease
Gene Frequency
Cardiovascular Diseases
Alleles

Keywords

  • Allelic polymorphism
  • Chimeric CYP11B2/CYP11B1 gene
  • Genes of the renin-angiotensin-aldosterone system
  • Hyperaldosteronism
  • Low-renin arterial hypertension
  • PCR

ASJC Scopus subject areas

  • Genetics

Cite this

Chikhladze, N. M., Samedova, K. F., Sudomoina, M. A., Min, K., Koliadina, J. A., Litonova, G. N., ... Favorova, O. O. (2008). Comparative genetic analysis of different forms of low-renin arterial hypertension. Molecular Biology, 42(4), 521-530. https://doi.org/10.1134/S0026893308040067

Comparative genetic analysis of different forms of low-renin arterial hypertension. / Chikhladze, N. M.; Samedova, Kh F.; Sudomoina, M. A.; Min, Ko; Koliadina, Ju A.; Litonova, G. N.; Favorov, Alexander; Chazova, I. E.; Favorova, O. O.

In: Molecular Biology, Vol. 42, No. 4, 08.2008, p. 521-530.

Research output: Contribution to journalArticle

Chikhladze, NM, Samedova, KF, Sudomoina, MA, Min, K, Koliadina, JA, Litonova, GN, Favorov, A, Chazova, IE & Favorova, OO 2008, 'Comparative genetic analysis of different forms of low-renin arterial hypertension', Molecular Biology, vol. 42, no. 4, pp. 521-530. https://doi.org/10.1134/S0026893308040067
Chikhladze NM, Samedova KF, Sudomoina MA, Min K, Koliadina JA, Litonova GN et al. Comparative genetic analysis of different forms of low-renin arterial hypertension. Molecular Biology. 2008 Aug;42(4):521-530. https://doi.org/10.1134/S0026893308040067
Chikhladze, N. M. ; Samedova, Kh F. ; Sudomoina, M. A. ; Min, Ko ; Koliadina, Ju A. ; Litonova, G. N. ; Favorov, Alexander ; Chazova, I. E. ; Favorova, O. O. / Comparative genetic analysis of different forms of low-renin arterial hypertension. In: Molecular Biology. 2008 ; Vol. 42, No. 4. pp. 521-530.
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