Comparative efficacy of ceftriaxone in experimental infections involving bacteroides fragilis and escherichia coli

Manoucher Dezfulian, Roger A. Bitar, John G. Bartlett

Research output: Contribution to journalArticlepeer-review

Abstract

The in vivo activity of ceftriaxone was examined in an experimentally induced subcutaneous infection involving Bacteroides fragilis and Escherichia coli. Mice were challenged with 1 of 10 strains of B. fragilis or E. coli, or a dual combination of the two species. The efficacy was measured by a reduction in the count of viable organisms when antimicrobial treatment was initiated 1 h after challenge and continued for 5 days. Ceftriaxone exhibited impressive activity against E. coli but showed poor in vivo activity versus B. fragilis. The antimicrobial activity of ceftriaxone was influenced by the microbial interaction in our dualisolate model. Pharmacokinetic studies showed that ceftriaxone penetrated into abscesses and achieved peak levels of about 40% of the peak serum levels. However, in abscesses infected with B. fragilis nearly all biological activity of ceftriaxone was lost.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalCHEMOTHERAPY
Volume39
Issue number5
DOIs
StatePublished - Jan 1 1993

Keywords

  • Bacteroides fragilis
  • Ceftriaxone
  • Escherichia coli
  • In vivo efficacy
  • Pharmacokinetics
  • Subcutaneous abscess

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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