Comparative effects of negative pions, neutrons, and photons on testes weight loss and spermatogenic stem-cell survival in mice

J. P. Geraci, J. F. Dicello, J. Eenmaa

Research output: Contribution to journalArticlepeer-review

Abstract

A comparison of the relative biological potency of fast neutrons, negative pions, and photons was made with decrease in testes weight and spermatogenic cell survival as endpoints. The predominant effect on these endpoints of the different LET radiations was a change in the slopes of the dose-response curves. Since the relative changes in slopes to different LET radiations were approximately the same for each endpoint, both endpoints yielded similar estimates of relative biological potency. The relative biological potency of neutrons, peak pions, and plateau pions relative to 137Cs γ rays or 300-kVp X rays for producing testicular damage were, respectively, 2.8, 1.5, and 1.2.

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalRadiation research
Volume81
Issue number3
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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