Comparative Effects of Glycogen and Antigen-Antibody Reactions on Serotonin and Histamine in the Rabbit

T. Phillip Waalkes, Harriette Coburn

Research output: Contribution to journalArticle

Abstract

When glycogen is incubated with normal rabbit blood, both serotonin and histamine are released from the platelets. EDTA inhibits this release. Intravenous injection of glycogen into rabbits produces a marked fall in whole blood concentration and a rise in lung content of serotonin and histamine. These results are secondary to trapping of platelets in the lung. In addition, both serotonin and histamine are released into the plasma. All of these changes are identical to those obtained when antigen is injected intravenously into a sensitized rabbit or when an antigen-antibody complex precipitate is injected intravenously into a normal rabbit.

Original languageEnglish (US)
Pages (from-to)122-125
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume101
Issue number1
DOIs
StatePublished - May 1959

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Comparative Effects of Glycogen and Antigen-Antibody Reactions on Serotonin and Histamine in the Rabbit'. Together they form a unique fingerprint.

  • Cite this