Comparative effectiveness of management options for patients with small renal masses

a prospective cohort study

Ridwan Alam, Hiten D. Patel, Tijani Osumah, Arnav Srivastava, Michael Gorin, Michael Johnson, Bruce Trock, Peter Chang, Andrew A. Wagner, James M. McKiernan, Mohamad E Allaf, Phillip Martin Pierorazio

Research output: Contribution to journalArticle

Abstract

Objectives: To explore the comparative effectiveness of partial nephrectomy (PN), radical nephrectomy (RN), ablative therapies (ablation) and active surveillance (AS) for small renal masses (SRMs; tumour diameter ≤4.0 cm) in the domains of survival, renal function and quality of life (QoL) using the prospectively maintained Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry. Patients and Methods: Estimated glomerular filtration rate (eGFR) was calculated from creatinine values to determine renal function. QoL was measured using the Short Form 12 (SF-12) questionnaire. The Kaplan–Meier method and Cox proportional hazards regression were used for survival analysis. The mixed-effects model was used for renal function and QoL analysis. Results: Of 638 patients, 231 (36.2%) chose PN, 41 (6.4%) RN, 27 (4.2%) ablation and 339 (53.1%) AS. Cancer-specific survival at 7 years was 98.8% in PN patients and 100% in all other groups. Overall survival (OS) at 7 years was 87.9%, 90.2%, 83.5% and 66.1% in PN, RN, ablation and AS patients, respectively. The OS rate was significantly worse in the AS group than other groups and likely attributable to older age and increased comorbidities. The eGFR was lowest in RN patients but comparable in all other groups. QoL was lowest in AS patients due to lower physical health scores, but mental health scores were similar in all groups. Conclusions: With excellent oncological outcomes in all groups, nephron-sparing approaches, like PN and ablation, are preferred over RN when intervention is indicated for SRMs. AS is a reasonable option for select patients, given the comparable oncological and mental health outcomes.

Original languageEnglish (US)
JournalBJU International
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Nephrectomy
Cohort Studies
Prospective Studies
Kidney
Quality of Life
Glomerular Filtration Rate
Survival
Mental Health
Nephrons
Survival Analysis
Registries
Comorbidity
Creatinine
Neoplasms
Survival Rate
Health

Keywords

  • active surveillance
  • quality of life
  • renal function
  • renal surgery
  • small renal mass

ASJC Scopus subject areas

  • Urology

Cite this

Comparative effectiveness of management options for patients with small renal masses : a prospective cohort study. / Alam, Ridwan; Patel, Hiten D.; Osumah, Tijani; Srivastava, Arnav; Gorin, Michael; Johnson, Michael; Trock, Bruce; Chang, Peter; Wagner, Andrew A.; McKiernan, James M.; Allaf, Mohamad E; Pierorazio, Phillip Martin.

In: BJU International, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Objectives: To explore the comparative effectiveness of partial nephrectomy (PN), radical nephrectomy (RN), ablative therapies (ablation) and active surveillance (AS) for small renal masses (SRMs; tumour diameter ≤4.0 cm) in the domains of survival, renal function and quality of life (QoL) using the prospectively maintained Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry. Patients and Methods: Estimated glomerular filtration rate (eGFR) was calculated from creatinine values to determine renal function. QoL was measured using the Short Form 12 (SF-12) questionnaire. The Kaplan–Meier method and Cox proportional hazards regression were used for survival analysis. The mixed-effects model was used for renal function and QoL analysis. Results: Of 638 patients, 231 (36.2{\%}) chose PN, 41 (6.4{\%}) RN, 27 (4.2{\%}) ablation and 339 (53.1{\%}) AS. Cancer-specific survival at 7 years was 98.8{\%} in PN patients and 100{\%} in all other groups. Overall survival (OS) at 7 years was 87.9{\%}, 90.2{\%}, 83.5{\%} and 66.1{\%} in PN, RN, ablation and AS patients, respectively. The OS rate was significantly worse in the AS group than other groups and likely attributable to older age and increased comorbidities. The eGFR was lowest in RN patients but comparable in all other groups. QoL was lowest in AS patients due to lower physical health scores, but mental health scores were similar in all groups. Conclusions: With excellent oncological outcomes in all groups, nephron-sparing approaches, like PN and ablation, are preferred over RN when intervention is indicated for SRMs. AS is a reasonable option for select patients, given the comparable oncological and mental health outcomes.",
keywords = "active surveillance, quality of life, renal function, renal surgery, small renal mass",
author = "Ridwan Alam and Patel, {Hiten D.} and Tijani Osumah and Arnav Srivastava and Michael Gorin and Michael Johnson and Bruce Trock and Peter Chang and Wagner, {Andrew A.} and McKiernan, {James M.} and Allaf, {Mohamad E} and Pierorazio, {Phillip Martin}",
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T1 - Comparative effectiveness of management options for patients with small renal masses

T2 - a prospective cohort study

AU - Alam, Ridwan

AU - Patel, Hiten D.

AU - Osumah, Tijani

AU - Srivastava, Arnav

AU - Gorin, Michael

AU - Johnson, Michael

AU - Trock, Bruce

AU - Chang, Peter

AU - Wagner, Andrew A.

AU - McKiernan, James M.

AU - Allaf, Mohamad E

AU - Pierorazio, Phillip Martin

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: To explore the comparative effectiveness of partial nephrectomy (PN), radical nephrectomy (RN), ablative therapies (ablation) and active surveillance (AS) for small renal masses (SRMs; tumour diameter ≤4.0 cm) in the domains of survival, renal function and quality of life (QoL) using the prospectively maintained Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry. Patients and Methods: Estimated glomerular filtration rate (eGFR) was calculated from creatinine values to determine renal function. QoL was measured using the Short Form 12 (SF-12) questionnaire. The Kaplan–Meier method and Cox proportional hazards regression were used for survival analysis. The mixed-effects model was used for renal function and QoL analysis. Results: Of 638 patients, 231 (36.2%) chose PN, 41 (6.4%) RN, 27 (4.2%) ablation and 339 (53.1%) AS. Cancer-specific survival at 7 years was 98.8% in PN patients and 100% in all other groups. Overall survival (OS) at 7 years was 87.9%, 90.2%, 83.5% and 66.1% in PN, RN, ablation and AS patients, respectively. The OS rate was significantly worse in the AS group than other groups and likely attributable to older age and increased comorbidities. The eGFR was lowest in RN patients but comparable in all other groups. QoL was lowest in AS patients due to lower physical health scores, but mental health scores were similar in all groups. Conclusions: With excellent oncological outcomes in all groups, nephron-sparing approaches, like PN and ablation, are preferred over RN when intervention is indicated for SRMs. AS is a reasonable option for select patients, given the comparable oncological and mental health outcomes.

AB - Objectives: To explore the comparative effectiveness of partial nephrectomy (PN), radical nephrectomy (RN), ablative therapies (ablation) and active surveillance (AS) for small renal masses (SRMs; tumour diameter ≤4.0 cm) in the domains of survival, renal function and quality of life (QoL) using the prospectively maintained Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry. Patients and Methods: Estimated glomerular filtration rate (eGFR) was calculated from creatinine values to determine renal function. QoL was measured using the Short Form 12 (SF-12) questionnaire. The Kaplan–Meier method and Cox proportional hazards regression were used for survival analysis. The mixed-effects model was used for renal function and QoL analysis. Results: Of 638 patients, 231 (36.2%) chose PN, 41 (6.4%) RN, 27 (4.2%) ablation and 339 (53.1%) AS. Cancer-specific survival at 7 years was 98.8% in PN patients and 100% in all other groups. Overall survival (OS) at 7 years was 87.9%, 90.2%, 83.5% and 66.1% in PN, RN, ablation and AS patients, respectively. The OS rate was significantly worse in the AS group than other groups and likely attributable to older age and increased comorbidities. The eGFR was lowest in RN patients but comparable in all other groups. QoL was lowest in AS patients due to lower physical health scores, but mental health scores were similar in all groups. Conclusions: With excellent oncological outcomes in all groups, nephron-sparing approaches, like PN and ablation, are preferred over RN when intervention is indicated for SRMs. AS is a reasonable option for select patients, given the comparable oncological and mental health outcomes.

KW - active surveillance

KW - quality of life

KW - renal function

KW - renal surgery

KW - small renal mass

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