Comparative effect of tetracycline and doxycycline on the occurrence of resistant Escherichia coli in the fecal flora

J. G. Bartlett, L. A. Bustetter, S. L. Gorbach, A. B. Onderdonk

Research output: Contribution to journalArticle

Abstract

Antiobiotic induced changes in the fecal microflora after oral administration of tetracycline hydrochloride and doxycycline for 8 to 10 days were compared. A significant difference was noted in the concentrations of Escherichia coli resistant to tetracyclines. With tetracycline hydrochloride, there was a mean increase of approximately 104 resistant strains per g compared to only 101/g for doxycycline. This difference is ascribed to reduced intestinal concentrations of bioactive drug with recommended oral dosage for doxycycline.

Original languageEnglish (US)
Pages (from-to)55-57
Number of pages3
JournalANTIMICROB.AGENTS CHEMOTHER.
Volume7
Issue number1
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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