Comparative effect of tetracycline and doxycycline on the occurrence of resistant Escherichia coli in the fecal flora

J. G. Bartlett; L. A. Bustetter; S. L. Gorbach; A. B. Onderdonk

doi:10.1128/AAC.7.1.55

Comparative effect of tetracycline and doxycycline on the occurrence of resistant Escherichia coli in the fecal flora

J. G. Bartlett, L. A. Bustetter, S. L. Gorbach, A. B. Onderdonk

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Antiobiotic induced changes in the fecal microflora after oral administration of tetracycline hydrochloride and doxycycline for 8 to 10 days were compared. A significant difference was noted in the concentrations of Escherichia coli resistant to tetracyclines. With tetracycline hydrochloride, there was a mean increase of approximately 10⁴ resistant strains per g compared to only 10¹/g for doxycycline. This difference is ascribed to reduced intestinal concentrations of bioactive drug with recommended oral dosage for doxycycline.

Original language	English (US)
Pages (from-to)	55-57
Number of pages	3
Journal	ANTIMICROB.AGENTS CHEMOTHER.
Volume	7
Issue number	1
DOIs	https://doi.org/10.1128/AAC.7.1.55
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Antiobiotic induced changes in the fecal microflora after oral administration of tetracycline hydrochloride and doxycycline for 8 to 10 days were compared. A significant difference was noted in the concentrations of Escherichia coli resistant to tetracyclines. With tetracycline hydrochloride, there was a mean increase of approximately 104 resistant strains per g compared to only 101/g for doxycycline. This difference is ascribed to reduced intestinal concentrations of bioactive drug with recommended oral dosage for doxycycline.",

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AU - Gorbach, S. L.

AU - Onderdonk, A. B.

PY - 1975

Y1 - 1975

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AB - Antiobiotic induced changes in the fecal microflora after oral administration of tetracycline hydrochloride and doxycycline for 8 to 10 days were compared. A significant difference was noted in the concentrations of Escherichia coli resistant to tetracyclines. With tetracycline hydrochloride, there was a mean increase of approximately 104 resistant strains per g compared to only 101/g for doxycycline. This difference is ascribed to reduced intestinal concentrations of bioactive drug with recommended oral dosage for doxycycline.

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Comparative effect of tetracycline and doxycycline on the occurrence of resistant Escherichia coli in the fecal flora

Abstract

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