Comparative dose efficacy of statins

P. H. Jones, R. S. Blumenthal

Research output: Contribution to journalArticle

Abstract

We compared the efficacy of atorvastatin with pravastatin, simvastatin, fluvastatin, and lovastatin in 534 hypercholesterolemic patients in an 8- week, multicenter, randomized, open-label, parallel-group study. Atorvastatin 10, 20, and 40 mg produced significantly greater reductions (p ≤ .01) from baseline in low-density lipoprotein cholesterol and in total cholesterol than the milligram-equivalent doses of simvastatin, pravastatin, lovastatin, and fluvastatin. Safety profiles and tolerability wer similar for all the statins in this study.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalCardiology Review
Volume15
Issue number12
StatePublished - Jan 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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