Comparative chromosome band mapping in primates by in situ suppression hybridization of band specific DNA microlibraries

C. Lengauer, J. Wienberg, T. Cremer, H. J. Lüdecke, B. Horsthemke

Research output: Contribution to journalArticlepeer-review

Abstract

A DNA-library established from microdissected bands 8q23 to 8q24.1 of normal human chromosomes 8 (Lüdecke et al., 1989) was used as a probe for chromosomal in situ suppression (CISS-) hybridization to metaphase chromosomes of man and primates including Hylobates lar and Macaca fuscata. Comparative band mapping as first applied in this study shows the specific visualization of a single subchromosomal region in all three species and thus demonstrates that synteny of the bulk sequences of a specific human chromosome subregion has been conserved for more than 20 million years.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalHuman Evolution
Volume6
Issue number1
DOIs
StatePublished - Feb 1991
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Fingerprint

Dive into the research topics of 'Comparative chromosome band mapping in primates by in situ suppression hybridization of band specific DNA microlibraries'. Together they form a unique fingerprint.

Cite this