Comparative analysis of apicomplexa and genomic diversity in eukaryotes

Thomas J. Templeton, Lakshminarayan M. Iyer, Vivek Anantharaman, Shinichiro Enomoto, Juan E. Abrahante, G. M. Subramanian, Stephen L. Hoffman, Mitchell S. Abrahamsen, L. Aravind

Research output: Contribution to journalArticle

Abstract

The apicomplexans Plasmodium and Cryptosporidium have developed distinctive adaptations via lineage-specific gene loss and gene innovation in the process of diverging from a common parasitic ancestor. The two lineages have acquired distinct but overlapping sets of surface protein adhesion domains typical of animal proteins, but in no case do they share multidomain architectures identical to animals. Cryptosporidium, but not Plasmodium, possesses an animal-type O-linked glycosylation pathway, along with >30 predicted surface proteins having mucin-like segments. The two parasites have notable qualitative differences in conserved protein architectures associated with chromatin dynamics and transcription. Cryptosporidium shows considerable reduction in the number of introns and a concomitant loss of spliceosomal machinery components. We also describe additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available.

Original languageEnglish (US)
Pages (from-to)1686-1695
Number of pages10
JournalGenome Research
Volume14
Issue number9
DOIs
StatePublished - Sep 2004
Externally publishedYes

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Apicomplexa
Cryptosporidium
Eukaryota
Plasmodium
Membrane Proteins
Mucins
Glycosylation
Introns
Genes
Chromatin
Parasites
Proteins
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

Templeton, T. J., Iyer, L. M., Anantharaman, V., Enomoto, S., Abrahante, J. E., Subramanian, G. M., ... Aravind, L. (2004). Comparative analysis of apicomplexa and genomic diversity in eukaryotes. Genome Research, 14(9), 1686-1695. https://doi.org/10.1101/gr.2615304

Comparative analysis of apicomplexa and genomic diversity in eukaryotes. / Templeton, Thomas J.; Iyer, Lakshminarayan M.; Anantharaman, Vivek; Enomoto, Shinichiro; Abrahante, Juan E.; Subramanian, G. M.; Hoffman, Stephen L.; Abrahamsen, Mitchell S.; Aravind, L.

In: Genome Research, Vol. 14, No. 9, 09.2004, p. 1686-1695.

Research output: Contribution to journalArticle

Templeton, TJ, Iyer, LM, Anantharaman, V, Enomoto, S, Abrahante, JE, Subramanian, GM, Hoffman, SL, Abrahamsen, MS & Aravind, L 2004, 'Comparative analysis of apicomplexa and genomic diversity in eukaryotes', Genome Research, vol. 14, no. 9, pp. 1686-1695. https://doi.org/10.1101/gr.2615304
Templeton TJ, Iyer LM, Anantharaman V, Enomoto S, Abrahante JE, Subramanian GM et al. Comparative analysis of apicomplexa and genomic diversity in eukaryotes. Genome Research. 2004 Sep;14(9):1686-1695. https://doi.org/10.1101/gr.2615304
Templeton, Thomas J. ; Iyer, Lakshminarayan M. ; Anantharaman, Vivek ; Enomoto, Shinichiro ; Abrahante, Juan E. ; Subramanian, G. M. ; Hoffman, Stephen L. ; Abrahamsen, Mitchell S. ; Aravind, L. / Comparative analysis of apicomplexa and genomic diversity in eukaryotes. In: Genome Research. 2004 ; Vol. 14, No. 9. pp. 1686-1695.
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