Comparative activity and distribution studies of five platinum analogues in nude mice bearing human ovarian carcinoma xenografts

E. Boven, W. J F van der Vijgh, M. M. Nauta, H. M. Schlüper, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

The antitumor activity of four new platinum analogues was compared at equitoxic doses to that of cisplatin in B10 LP/cpb nude mice bearing xenografts of human ovarian carcinomas. The two tumor lines used, MRI-H-207 and Pe, differ in histology, tumor doubling time, and sensitivity to cisplatin. Complete remission of MRI-H-207 was observed with cisplatin, carboplatin, iproplatin, and JM-40, while spiroplatin only gave growth delay. Cisplatin and carboplatin caused some growth delay of Pe, while JM-40, spiroplatin, and iproplatin failed to affect tumor growth. Platinum tissue distribution was also measured for each compound in groups of five to seven tumor-bearing mice. Platinum concentrations in the two tumors at 24 hr were similar for cisplatin and carboplatin, but differed for iproplatin, spiroplatin, and JM-40. Organ distribution was similar for each analogue, and concentrations were significantly higher in kidneys than in liver, except for iproplatin with comparable concentrations in these organs. Our findings show a good correlation between analogue activity in ovarian cancer in the clinic and that in MRI-H-207. Platinum concentrations in tumor tissue did not predict antitumor activity.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalCancer Research
Volume45
Issue number1
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Comparative activity and distribution studies of five platinum analogues in nude mice bearing human ovarian carcinoma xenografts'. Together they form a unique fingerprint.

Cite this