TY - JOUR
T1 - Comparable seizure characteristics in magnetic seizure therapy and electroconvulsive therapy for major depression
AU - Kayser, Sarah
AU - Bewernick, Bettina H.
AU - Hurlemann, René
AU - Soehle, Martin
AU - Schlaepfer, Thomas E.
N1 - Funding Information:
SK was supported by a Grant of MagVenture A/S Inc. for lectures. BB had no conflict of interests. RH was supported by a German Research Foundation (DFG) grant (HU1302/ 2-2) and by a Starting Independent Researcher Grant jointly provided by the Ministry of Innovation, Science, Research and Technology of the German State of North Rhine-Westphalia (MIWFT) and the University of Bonn. MS had received honoraria for lectures from Covidien Germany (Neustadt/Donau, Germany). This investigator-initiated study was supported in part (loan of MST device) by a Grant MagVenture A/S Inc. to TS.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression (TRD); however, its use for less severe forms of depression is somewhat limited by a lack of control over current spreading to medial temporal lobe memory structures, resulting in various cognitive side effects. In contrast, magnetic seizure therapy (MST), which uses high frequency repetitive transcranial magnetic stimulation (rTMS) for local seizure induction, has been associated with reduced cognitive side effects. To assess whether different characteristics of seizures induced by both methods are responsible for the differences in neuropsychological side-effect profile, we studied seven TRD-patients undergoing both MST and ECT in an open-label, within subject, controlled crossover pilot study. Comparison parameters included seizure-related ictal characteristics, including motor activity, electromyogram (EMG), electroencephalogram (EEG), and postictal recovery and reorientation times.Our results showed no differences in motor activity or EMG and EEG characteristics, thus implicating similar electrophysiological processes in seizure induction with MST and ECT. In line with previous studies, we observed shorter postictal recovery and reorientation times following MST.The ictal characteristics of induced seizures were found similar with ECT and MST suggesting that the more focal seizure induction associated with MST may account for the more beneficial neuropsychological side effect profile of MST.
AB - Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression (TRD); however, its use for less severe forms of depression is somewhat limited by a lack of control over current spreading to medial temporal lobe memory structures, resulting in various cognitive side effects. In contrast, magnetic seizure therapy (MST), which uses high frequency repetitive transcranial magnetic stimulation (rTMS) for local seizure induction, has been associated with reduced cognitive side effects. To assess whether different characteristics of seizures induced by both methods are responsible for the differences in neuropsychological side-effect profile, we studied seven TRD-patients undergoing both MST and ECT in an open-label, within subject, controlled crossover pilot study. Comparison parameters included seizure-related ictal characteristics, including motor activity, electromyogram (EMG), electroencephalogram (EEG), and postictal recovery and reorientation times.Our results showed no differences in motor activity or EMG and EEG characteristics, thus implicating similar electrophysiological processes in seizure induction with MST and ECT. In line with previous studies, we observed shorter postictal recovery and reorientation times following MST.The ictal characteristics of induced seizures were found similar with ECT and MST suggesting that the more focal seizure induction associated with MST may account for the more beneficial neuropsychological side effect profile of MST.
KW - Electroconvulsive therapy
KW - Electroencephalogram
KW - Ictal characteristics
KW - Magnetic seizure therapy
KW - Treatment-resistant depression
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U2 - 10.1016/j.euroneuro.2013.04.011
DO - 10.1016/j.euroneuro.2013.04.011
M3 - Article
C2 - 23820052
AN - SCOPUS:84886769115
SN - 0924-977X
VL - 23
SP - 1541
EP - 1550
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 11
ER -