TY - JOUR
T1 - Community walking speed, sedentary or lying down time, and mortality in peripheral artery disease
AU - McDermott, Mary M.
AU - Guralnik, Jack M.
AU - Ferrucci, Luigi
AU - Tian, Lu
AU - Kibbe, Melina R.
AU - Greenland, Philip
AU - Green, David
AU - Liu, Kiang
AU - Zhao, Lihui
AU - Wilkins, John T.
AU - Huffman, Mark D.
AU - Shah, Sanjiv J.
AU - Liao, Yihua
AU - Gao, Ying
AU - Lloyd-Jones, Donald M.
AU - Criqui, Michael H.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - We studied whether slower community walking speed and whether greater time spent lying down or sleeping were associated with higher mortality in people with lower extremity peripheral artery disease (PAD). Participants with an ankle-brachial index (ABI) <0.90 were identified from Chicago medical centers. At baseline, participants reported their usual walking speed outside their home and the number of hours they spent lying down or sleeping per day. Cause of death was adjudicated using death certificates and medical record review. Analyses were adjusted for age, sex, race, comorbidities, ABI, and other confounders. Of 1314 PAD participants, 189 (14.4%) died, including 63 cardiovascular disease (CVD) deaths. Mean follow-up was 34.9 months ± 18.1. Relative to average or normal pace (2-3 miles/hour), slower walking speed was associated with greater CVD mortality: no walking at all: hazard ratio (HR) = 4.17, 95% confidence interval (CI) = 1.46-11.89; casual strolling (0-2 miles/hour): HR = 2.24, 95% CI = 1.16-4.32; brisk or striding (>3 miles/hour): HR = 0.55, 95% CI = 0.07-4.30. These associations were not significant after additional adjustment for the six-minute walk. Relative to sleeping or lying down for 8-9 hours, fewer or greater hours sleeping or lying down were associated with higher CVD mortality: 4-7 hours: HR = 2.08, 95% CI = 1.06-4.05; 10-11 hours: HR = 4.07, 95% CI = 1.86-8.89;
AB - We studied whether slower community walking speed and whether greater time spent lying down or sleeping were associated with higher mortality in people with lower extremity peripheral artery disease (PAD). Participants with an ankle-brachial index (ABI) <0.90 were identified from Chicago medical centers. At baseline, participants reported their usual walking speed outside their home and the number of hours they spent lying down or sleeping per day. Cause of death was adjudicated using death certificates and medical record review. Analyses were adjusted for age, sex, race, comorbidities, ABI, and other confounders. Of 1314 PAD participants, 189 (14.4%) died, including 63 cardiovascular disease (CVD) deaths. Mean follow-up was 34.9 months ± 18.1. Relative to average or normal pace (2-3 miles/hour), slower walking speed was associated with greater CVD mortality: no walking at all: hazard ratio (HR) = 4.17, 95% confidence interval (CI) = 1.46-11.89; casual strolling (0-2 miles/hour): HR = 2.24, 95% CI = 1.16-4.32; brisk or striding (>3 miles/hour): HR = 0.55, 95% CI = 0.07-4.30. These associations were not significant after additional adjustment for the six-minute walk. Relative to sleeping or lying down for 8-9 hours, fewer or greater hours sleeping or lying down were associated with higher CVD mortality: 4-7 hours: HR = 2.08, 95% CI = 1.06-4.05; 10-11 hours: HR = 4.07, 95% CI = 1.86-8.89;
KW - cardiovascular mortality
KW - cardiovascular risk factors
KW - intermittent claudication
KW - modifiable behaviors
KW - peripheral artery disease
KW - physical activity
KW - sedentary
KW - six-minute walk test
UR - http://www.scopus.com/inward/record.url?scp=84961244414&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961244414&partnerID=8YFLogxK
U2 - 10.1177/1358863X15626521
DO - 10.1177/1358863X15626521
M3 - Article
C2 - 26873873
AN - SCOPUS:84961244414
SN - 1358-863X
VL - 21
SP - 120
EP - 129
JO - Vascular Medicine
JF - Vascular Medicine
IS - 2
ER -