Community infection ratio as an indicator for tuberculosis control

G. Madico, Robert H Gilman, L. Cabrera, K. Kacena, J. F. Díaz, R. H. Gilman, William Checkley, I. Kohlstadt, Robert E Black

Research output: Contribution to journalArticle

Abstract

The epidemiology of tuberculosis remains poorly understood. We investigated the relative importance of within-household and community transmission of infection among children aged 6 months to 14 years living in a Peruvian shanty-town. The prevalence of Mycobacterium tuberculosis exposure among 175 contact children (sharing a household with a person who had confirmed pulmonary tuberculosis) and 382 control children (living in nearby households free of active tuberculosis) was defined as the proportion of children with a positive purified protein derivative (PPD) skin-test. 97 (55%) contact children and 129 (34%) controls were PPD positive. Living in a contact household (odds ratio 1·74, 95% Cl 1·11-2·73) and age (1·11, 1·06-1·18) were significant risk factors for PPD positivity. We calculated the community infection ratio (CIR) as the odds ratio of PPD-positive controls to PPD-positive contacts: CIR=Prevalence in controls/(1-prevalence in controls) Prevalence in contacts/(1-prevalence in contacts) A low CIR therefore suggests mainly household spread of infection, whereas a high value suggests frequent transmission outside the household. The adjusted odds ratio (for age, sex, within-household correlation, and household size) was 0·40 (95% Cl 0·26-0·64), compared with values of 0·18-0·37 in studies elsewhere. Currently recommended tuberculosis control strategies are suitable for areas with low CIRs. Different strategies may be needed for areas, such as that we studied, with high values.

Original languageEnglish (US)
Pages (from-to)416-419
Number of pages4
JournalThe Lancet
Volume345
Issue number8947
DOIs
StatePublished - Feb 18 1995

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Tuberculosis
Infection
Odds Ratio
Proteins
Infectious Disease Transmission
Skin Tests
Pulmonary Tuberculosis
Mycobacterium tuberculosis
Epidemiology

ASJC Scopus subject areas

  • Medicine(all)

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Community infection ratio as an indicator for tuberculosis control. / Madico, G.; Gilman, Robert H; Cabrera, L.; Kacena, K.; Díaz, J. F.; Gilman, R. H.; Checkley, William; Kohlstadt, I.; Black, Robert E.

In: The Lancet, Vol. 345, No. 8947, 18.02.1995, p. 416-419.

Research output: Contribution to journalArticle

Madico, G, Gilman, RH, Cabrera, L, Kacena, K, Díaz, JF, Gilman, RH, Checkley, W, Kohlstadt, I & Black, RE 1995, 'Community infection ratio as an indicator for tuberculosis control', The Lancet, vol. 345, no. 8947, pp. 416-419. https://doi.org/10.1016/S0140-6736(95)90401-8
Madico G, Gilman RH, Cabrera L, Kacena K, Díaz JF, Gilman RH et al. Community infection ratio as an indicator for tuberculosis control. The Lancet. 1995 Feb 18;345(8947):416-419. https://doi.org/10.1016/S0140-6736(95)90401-8
Madico, G. ; Gilman, Robert H ; Cabrera, L. ; Kacena, K. ; Díaz, J. F. ; Gilman, R. H. ; Checkley, William ; Kohlstadt, I. ; Black, Robert E. / Community infection ratio as an indicator for tuberculosis control. In: The Lancet. 1995 ; Vol. 345, No. 8947. pp. 416-419.
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