Community-acquired pneumonia in immunocompromised older patients: Incidence, causative organisms and outcome

D. Sousa; I. Justo; A. Domínguez; A. Manzur; C. Izquierdo; L. Ruiz; M. Nebot; J. M. Bayas; J. M. Celorrio; W. Varona; P. Llinares; E. Miguez; E. Sánchez; J. Carratalá

doi:10.1111/j.1469-0691.2012.03765.x

Community-acquired pneumonia in immunocompromised older patients: Incidence, causative organisms and outcome

D. Sousa, I. Justo, A. Domínguez, A. Manzur, C. Izquierdo, L. Ruiz, M. Nebot, J. M. Bayas, J. M. Celorrio, W. Varona, P. Llinares, E. Miguez, E. Sánchez, J. Carratalá

Research output: Contribution to journal › Article › peer-review

Abstract

The number of elderly patients in the community with immunosuppressive conditions has increased progressively over recent decades. We sought to determine the incidence, causative organisms and outcome of community-acquired pneumonia (CAP) occurring in immunocompromised older patients. We prospectively compared cases of CAP in immunocompromised and non-immunocompromised patients admitted to five public hospitals in three Spanish regions. Of 320 cases studied, 115 (36%) occurred in immunocompromised patients, including: solid or hematological malignancy (97), corticosteroids or other immunosuppressive drugs (44), solid organ or stem cell transplant (five), and other conditions (eight). The etiology was established in 44% of immunocompromised patients vs. 32% of non-immunocompromised patients (p0.03). Streptococcus pneumoniae was the most common causative organism in both groups (29% vs. 21%; p0.08), followed by Legionella pneumophila (3% vs. 6%; p0.01). Gram-negative bacilli were more frequent among immunocompromised patients (5% vs. 0.5%; p

Original language	English (US)
Pages (from-to)	187-192
Number of pages	6
Journal	Clinical Microbiology and Infection
Volume	19
Issue number	2
DOIs	https://doi.org/10.1111/j.1469-0691.2012.03765.x
State	Published - Feb 2013
Externally published	Yes

Keywords

CAP
Community-acquired pneumonia
Elderly
Immunocompromised
Immunosuppression

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Sousa, D., Justo, I., Domínguez, A., Manzur, A., Izquierdo, C., Ruiz, L., Nebot, M., Bayas, J. M., Celorrio, J. M., Varona, W., Llinares, P., Miguez, E., Sánchez, E., & Carratalá, J. (2013). Community-acquired pneumonia in immunocompromised older patients: Incidence, causative organisms and outcome. Clinical Microbiology and Infection, 19(2), 187-192. https://doi.org/10.1111/j.1469-0691.2012.03765.x

Community-acquired pneumonia in immunocompromised older patients : Incidence, causative organisms and outcome. / Sousa, D.; Justo, I.; Domínguez, A.; Manzur, A.; Izquierdo, C.; Ruiz, L.; Nebot, M.; Bayas, J. M.; Celorrio, J. M.; Varona, W.; Llinares, P.; Miguez, E.; Sánchez, E.; Carratalá, J.

In: Clinical Microbiology and Infection, Vol. 19, No. 2, 02.2013, p. 187-192.

Research output: Contribution to journal › Article › peer-review

Sousa, D, Justo, I, Domínguez, A, Manzur, A, Izquierdo, C, Ruiz, L, Nebot, M, Bayas, JM, Celorrio, JM, Varona, W, Llinares, P, Miguez, E, Sánchez, E & Carratalá, J 2013, 'Community-acquired pneumonia in immunocompromised older patients: Incidence, causative organisms and outcome', Clinical Microbiology and Infection, vol. 19, no. 2, pp. 187-192. https://doi.org/10.1111/j.1469-0691.2012.03765.x

Sousa, D. ; Justo, I. ; Domínguez, A. ; Manzur, A. ; Izquierdo, C. ; Ruiz, L. ; Nebot, M. ; Bayas, J. M. ; Celorrio, J. M. ; Varona, W. ; Llinares, P. ; Miguez, E. ; Sánchez, E. ; Carratalá, J. / Community-acquired pneumonia in immunocompromised older patients : Incidence, causative organisms and outcome. In: Clinical Microbiology and Infection. 2013 ; Vol. 19, No. 2. pp. 187-192.

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