Communication over a large distance: Enhancers and insulators

Vladimir A. Bondarenko, Ye V. Liu, Yong I. Jiang, Vasily M. Studitsky

Research output: Contribution to journalArticle

Abstract

Enhancers are regulatory DNA sequences that can work over a large distance. Efficient enhancer action over a distance clearly requires special mechanisms for facilitating communication between the enhancer and its target. While the chromatin looping model can explain the majority of the observations, some recent experimental findings suggest that a chromatin scanning mechanism is used to establish the loop. These new findings help to understand the mechanism of action of the elements that can prevent enhancer-promoter communication (insulators).

Original languageEnglish (US)
Pages (from-to)241-251
Number of pages11
JournalBiochemistry and Cell Biology
Volume81
Issue number3
DOIs
StatePublished - Jun 1 2003

Keywords

  • Chromatin
  • Enhancers
  • Insulators
  • Transcription activation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Bondarenko, V. A., Liu, Y. V., Jiang, Y. I., & Studitsky, V. M. (2003). Communication over a large distance: Enhancers and insulators. Biochemistry and Cell Biology, 81(3), 241-251. https://doi.org/10.1139/o03-051