Communication breakdown: The impact of ageing on synapse structure

Ronald S. Petralia; Mark P. Mattson; Pamela J. Yao

doi:10.1016/j.arr.2014.01.003

Communication breakdown: The impact of ageing on synapse structure

Ronald S. Petralia, Mark P. Mattson, Pamela J. Yao

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Impaired synaptic plasticity is implicated in the functional decline of the nervous system associated with ageing. Understanding the structure of ageing synapses is essential to understanding the functions of these synapses and their role in the ageing nervous system. In this review, we summarize studies on ageing synapses in vertebrates and invertebrates, focusing on changes in morphology and ultrastructure. We cover different parts of the nervous system, including the brain, the retina, the cochlea, and the neuromuscular junction. The morphological characteristics of aged synapses could shed light on the underlying molecular changes and their functional consequences.

Original language	English (US)
Pages (from-to)	31-42
Number of pages	12
Journal	Ageing Research Reviews
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.arr.2014.01.003
State	Published - 2014
Externally published	Yes

Keywords

Ageing
Dendritic spine
Neurotransmitter vesicles
Postsynaptic density
Presynaptic bouton
Synapse

ASJC Scopus subject areas

Aging
Biochemistry
Biotechnology
Molecular Biology
Neurology
Medicine(all)

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10.1016/j.arr.2014.01.003

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AU - Mattson, Mark P.

AU - Yao, Pamela J.

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AB - Impaired synaptic plasticity is implicated in the functional decline of the nervous system associated with ageing. Understanding the structure of ageing synapses is essential to understanding the functions of these synapses and their role in the ageing nervous system. In this review, we summarize studies on ageing synapses in vertebrates and invertebrates, focusing on changes in morphology and ultrastructure. We cover different parts of the nervous system, including the brain, the retina, the cochlea, and the neuromuscular junction. The morphological characteristics of aged synapses could shed light on the underlying molecular changes and their functional consequences.

KW - Ageing

KW - Dendritic spine

KW - Neurotransmitter vesicles

KW - Postsynaptic density

KW - Presynaptic bouton

KW - Synapse

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Communication breakdown: The impact of ageing on synapse structure

Abstract

Keywords

ASJC Scopus subject areas

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