Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer

Marc Y R Henrion, Mark P. Purdue, Ghislaine Scelo, Peter Broderick, Matthew Frampton, Alastair Ritchie, Angela Meade, Peng Li, James McKay, Mattias Johansson, Mark Lathrop, James Larkin, Nathaniel Rothman, Zhaoming Wang, Wong Ho Chow, Victoria L. Stevens, W. Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Paul Brennan & 3 others Timothy Eisen, Stephen Chanock, Richard S. Houlston

Research output: Contribution to journalArticle

Abstract

So far six susceptibility loci for renal cell carcinoma (RCC) have been discovered by genome-wide association studies (GWAS). To identify additional RCC common risk loci, we performed a meta-analysis of published GWAS (totalling 2,215 cases and 8,566 controls of Western-European background) with imputation using 1000 Genomes Project and UK10K Project data as reference panels and followed up the most significant association signals [22 single nucleotide polymorphisms (SNPs) and 3 indels in eight genomic regions] in 383 cases and 2,189 controls from The Cancer Genome Atlas (TCGA). A combined analysis identified a promising susceptibility locus mapping to 1q24.1 marked by the imputed SNP rs3845536 (Pcombined =2.30×10-8). Specifically, the signal maps to intron 4 of the ALDH9A1 gene (aldehyde dehydrogenase 9 family, member A1). We further evaluated this potential signal in 2,461 cases and 5,081 controls from the International Agency for Research on Cancer (IARC) GWAS of RCC cases and controls from multiple European regions. In contrast to earlier findings no association was shown in the IARC series (P=0.94; Pcombined=2.73×10-5). While variation at 1q24.1 represents a potential risk locus for RCC, future replication analyses are required to substantiate our observation.

Original languageEnglish (US)
Article numbere0122589
JournalPLoS One
Volume10
Issue number3
DOIs
StatePublished - Mar 31 2015
Externally publishedYes

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kidney neoplasms
Kidney Neoplasms
kidney cells
Renal Cell Carcinoma
carcinoma
Genome-Wide Association Study
risk factors
Genes
International Agencies
loci
single nucleotide polymorphism
neoplasms
Single Nucleotide Polymorphism
Genome
Polymorphism
aldehyde dehydrogenase
Neoplasms
Aldehyde Dehydrogenase
genome
Atlases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Henrion, M. Y. R., Purdue, M. P., Scelo, G., Broderick, P., Frampton, M., Ritchie, A., ... Houlston, R. S. (2015). Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer. PLoS One, 10(3), [e0122589]. https://doi.org/10.1371/journal.pone.0122589

Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer. / Henrion, Marc Y R; Purdue, Mark P.; Scelo, Ghislaine; Broderick, Peter; Frampton, Matthew; Ritchie, Alastair; Meade, Angela; Li, Peng; McKay, James; Johansson, Mattias; Lathrop, Mark; Larkin, James; Rothman, Nathaniel; Wang, Zhaoming; Chow, Wong Ho; Stevens, Victoria L.; Diver, W. Ryan; Albanes, Demetrius; Virtamo, Jarmo; Brennan, Paul; Eisen, Timothy; Chanock, Stephen; Houlston, Richard S.

In: PLoS One, Vol. 10, No. 3, e0122589, 31.03.2015.

Research output: Contribution to journalArticle

Henrion, MYR, Purdue, MP, Scelo, G, Broderick, P, Frampton, M, Ritchie, A, Meade, A, Li, P, McKay, J, Johansson, M, Lathrop, M, Larkin, J, Rothman, N, Wang, Z, Chow, WH, Stevens, VL, Diver, WR, Albanes, D, Virtamo, J, Brennan, P, Eisen, T, Chanock, S & Houlston, RS 2015, 'Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer', PLoS One, vol. 10, no. 3, e0122589. https://doi.org/10.1371/journal.pone.0122589
Henrion MYR, Purdue MP, Scelo G, Broderick P, Frampton M, Ritchie A et al. Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer. PLoS One. 2015 Mar 31;10(3). e0122589. https://doi.org/10.1371/journal.pone.0122589
Henrion, Marc Y R ; Purdue, Mark P. ; Scelo, Ghislaine ; Broderick, Peter ; Frampton, Matthew ; Ritchie, Alastair ; Meade, Angela ; Li, Peng ; McKay, James ; Johansson, Mattias ; Lathrop, Mark ; Larkin, James ; Rothman, Nathaniel ; Wang, Zhaoming ; Chow, Wong Ho ; Stevens, Victoria L. ; Diver, W. Ryan ; Albanes, Demetrius ; Virtamo, Jarmo ; Brennan, Paul ; Eisen, Timothy ; Chanock, Stephen ; Houlston, Richard S. / Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer. In: PLoS One. 2015 ; Vol. 10, No. 3.
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