Common variants within MECP2 confer risk of systemic lupus erythematosus

Amr H. Sawalha, Ryan Webb, Shizhong Han, Jennifer A. Kelly, Kenneth M. Kaufman, Robert P. Kimberly, Marta E. Alarcón-Riquelme, Judith A. James, Timothy J. Vyse, Gary S. Gilkeson, Chan Bum Choi, R. Hal Scofield, Sang Cheol Bae, Swapan K. Nath, John B. Harley

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic lupus erythematosus (SLE) is a predominantly female autoimmune disease that affects multiple organ systems. Herein, we report on an X-chromosome gene association with SLE, Methyl-CpG-binding protein 2 (MECP2) is located on chromosome Xq28 and encodes for a protein that plays a critical role in epigenetic regulation of methylation-sensitive genes. Utilizing a candidate gene association, we genotyped 21 SNPs within and around MECP2 in SLE patiehts and controls. We identify and replicate association between SLE and the genomic element containing MECP2 in two independent SLE cohorts from two ethnically divergent populations. These findings are potentially related to the overexpression of methylation sensitive genes in SLE.

Original languageEnglish (US)
Article numbere1727
JournalPloS one
Volume3
Issue number3
DOIs
StatePublished - Mar 5 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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