Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes

Susan L. Slager; Nicola J. Camp; Lucia Conde; Tait D. Shanafelt; Sara J. Achenbach; Kari G. Rabe; Neil E. Kay; Anne J. Novak; Timothy G. Call; Paige M. Bracci; Fenna M.C. Sille; Sylvia Sanchez; Nicholas K. Akers; Julie M. Cunningham; Daniel J. Serie; Shannon K. McDonnell; Jose F. Leis; Alice H. Wang; J. Brice Weinberg; Martha Glenn; Brian Link; Celine M. Vachon; Mark C. Lanasa; Christine F. Skibola; James R. Cerhan

doi:10.1111/bjh.12070

Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes

Susan L. Slager, Nicola J. Camp, Lucia Conde, Tait D. Shanafelt, Sara J. Achenbach, Kari G. Rabe, Neil E. Kay, Anne J. Novak, Timothy G. Call, Paige M. Bracci, Fenna M.C. Sille, Sylvia Sanchez, Nicholas K. Akers, Julie M. Cunningham, Daniel J. Serie, Shannon K. McDonnell, Jose F. Leis, Alice H. Wang, J. Brice Weinberg, Martha GlennBrian Link, Celine M. Vachon, Mark C. Lanasa, Christine F. Skibola, James R. Cerhan

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12 Scopus citations

Abstract

A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10^-3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.

Original language	English (US)
Pages (from-to)	572-576
Number of pages	5
Journal	British journal of haematology
Volume	159
Issue number	5
DOIs	https://doi.org/10.1111/bjh.12070
State	Published - Dec 2012
Externally published	Yes

Keywords

BAK 1
Chronic lymphocytic leukaemia
Non-Hodgkin lymphoma
Risk locus
Single nucleotide polymorphisms

ASJC Scopus subject areas

Hematology

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10.1111/bjh.12070

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Slager, S. L., Camp, N. J., Conde, L., Shanafelt, T. D., Achenbach, S. J., Rabe, K. G., Kay, N. E., Novak, A. J., Call, T. G., Bracci, P. M., Sille, F. M. C., Sanchez, S., Akers, N. K., Cunningham, J. M., Serie, D. J., McDonnell, S. K., Leis, J. F., Wang, A. H., Weinberg, J. B., ... Cerhan, J. R. (2012). Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. British journal of haematology, 159(5), 572-576. https://doi.org/10.1111/bjh.12070

Slager, SL, Camp, NJ, Conde, L, Shanafelt, TD, Achenbach, SJ, Rabe, KG, Kay, NE, Novak, AJ, Call, TG, Bracci, PM, Sille, FMC, Sanchez, S, Akers, NK, Cunningham, JM, Serie, DJ, McDonnell, SK, Leis, JF, Wang, AH, Weinberg, JB, Glenn, M, Link, B, Vachon, CM, Lanasa, MC, Skibola, CF & Cerhan, JR 2012, 'Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes', British journal of haematology, vol. 159, no. 5, pp. 572-576. https://doi.org/10.1111/bjh.12070

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title = "Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes",

abstract = "A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10-3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.",

keywords = "BAK 1, Chronic lymphocytic leukaemia, Non-Hodgkin lymphoma, Risk locus, Single nucleotide polymorphisms",

author = "Slager, {Susan L.} and Camp, {Nicola J.} and Lucia Conde and Shanafelt, {Tait D.} and Achenbach, {Sara J.} and Rabe, {Kari G.} and Kay, {Neil E.} and Novak, {Anne J.} and Call, {Timothy G.} and Bracci, {Paige M.} and Sille, {Fenna M.C.} and Sylvia Sanchez and Akers, {Nicholas K.} and Cunningham, {Julie M.} and Serie, {Daniel J.} and McDonnell, {Shannon K.} and Leis, {Jose F.} and Wang, {Alice H.} and Weinberg, {J. Brice} and Martha Glenn and Brian Link and Vachon, {Celine M.} and Lanasa, {Mark C.} and Skibola, {Christine F.} and Cerhan, {James R.}",

year = "2012",

month = dec,

doi = "10.1111/bjh.12070",

language = "English (US)",

volume = "159",

pages = "572--576",

journal = "British journal of haematology",

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T1 - Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes

AU - Slager, Susan L.

AU - Camp, Nicola J.

AU - Conde, Lucia

AU - Shanafelt, Tait D.

AU - Achenbach, Sara J.

AU - Rabe, Kari G.

AU - Kay, Neil E.

AU - Novak, Anne J.

AU - Call, Timothy G.

AU - Bracci, Paige M.

AU - Sille, Fenna M.C.

AU - Sanchez, Sylvia

AU - Akers, Nicholas K.

AU - Cunningham, Julie M.

AU - Serie, Daniel J.

AU - McDonnell, Shannon K.

AU - Leis, Jose F.

AU - Wang, Alice H.

AU - Weinberg, J. Brice

AU - Glenn, Martha

AU - Link, Brian

AU - Vachon, Celine M.

AU - Lanasa, Mark C.

AU - Skibola, Christine F.

AU - Cerhan, James R.

PY - 2012/12

Y1 - 2012/12

N2 - A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10-3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.

AB - A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10-3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.

KW - BAK 1

KW - Chronic lymphocytic leukaemia

KW - Non-Hodgkin lymphoma

KW - Risk locus

KW - Single nucleotide polymorphisms

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Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes

Abstract

Keywords

ASJC Scopus subject areas

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