Common variants of FUT2 are associated with plasma vitamin B12 levels

Aditi Hazra, Peter Kraft, Jacob Selhub, Edward L. Giovannucci, Gilles Thomas, Robert N. Hoover, Stephen J. Chanock, David J. Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

We identified a strong association (P = 5.36 × 10-17) between rs492602 in FUT2 and plasma vitamin B12 levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B12 levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B12 absorption and plasma levels.

Original languageEnglish (US)
Pages (from-to)1160-1162
Number of pages3
JournalNature genetics
Volume40
Issue number10
DOIs
StatePublished - Oct 2008

ASJC Scopus subject areas

  • Genetics

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