@article{85c897f11da84dfba463fb569c0c5842,
title = "Common variants in the GDF5-UQCC region are associated with variation in human height",
abstract = "Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic variants have been convincingly and reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population. Here we report genome-wide association analyses, using genotyped and imputed markers, of 6,669 individuals from Finland and Sardinia, and follow-up analyses in an additional 28,801 individuals. We show that common variants in the osteoarthritis- associated locus GDF5-UQCC contribute to variation in height with an estimated additive effect of 0.44 cm (overall P < 10-15). Our results indicate that there may be a link between the genetic basis of height and osteoarthritis, potentially mediated through alterations in bone growth and development.",
author = "Serena Sanna and Jackson, {Anne U.} and Ramaiah Nagaraja and Willer, {Cristen J.} and Chen, {Wei Min} and Bonnycastle, {Lori L.} and Haiqing Shen and Nicholas Timpson and Guillaume Lettre and Gianluca Usala and Chines, {Peter S.} and Stringham, {Heather M.} and Scott, {Laura J.} and Mariano Dei and Sandra Lai and Giuseppe Albai and Laura Crisponi and Silvia Naitza and Doheny, {Kimberly F.} and Pugh, {Elizabeth W.} and Yoav Ben-Shlomo and Shah Ebrahim and Lawlor, {Debbie A.} and Bergman, {Richard N.} and Watanabe, {Richard M.} and Manuela Uda and Jaakko Tuomilehto and Josef Coresh and Hirschhorn, {Joel N.} and Shuldiner, {Alan R.} and David Schlessinger and Collins, {Francis S.} and Smith, {George Davey} and Eric Boerwinkle and Antonio Cao and Michael Boehnke and Abecasis, {Gon{\c c}alo R.} and Mohlke, {Karen L.}",
note = "Funding Information: personnel of the ProgeNIA group in Lanusei. This research was supported (in part) by the intramural Research Program of the US National Institutes of Health (NIH) National Institute on Aging (contracts NO1-AG-1-2109 to the SardiNIA ({\textquoteleft}Progenia{\textquoteright}) team and 263-MA-410953 to the University of Michigan (G.R.A.)); NIH grants DK072193 (K.L.M.), HL084729 (G.R.A.), HG002651 (G.R.A.), DK062370 (M.B.), DK54361 (A.R.S.), HL72515 (A.R.S.), AG18728 (A.R.S.) and AR046838 (A.R.S.); the National Human Genome Research Institute (intramural project number 1 Z01 HG000024 (F.S.C.)); the American Diabetes Association, including a postdoctoral fellowship award (C.J.W.); and March of Dimes (research grant 6-FY04-61 (J.N.H.)). K.L.M. and G.R.A are Pew Scholars in the Biomedical Sciences. The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by the National Heart, Lung, and Blood Institute (contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021 and N01-HC-55022). FUSION GWAS genotyping was performed with support from CIDR NIH (contract N01-HG-65403) and the John Hopkins University Genetic Resources Core Facility SNP Center. The whole-genome genotyping and analysis in the Diabetic Genetics Initiative genome scan was supported by Novartis Institutes for BioMedical Research (to D. Altshuler), with additional support from The Richard and Susan Smith Family Foundation/American Diabetes Association Pinnacle Program Project Award (to D. Altshuler, J.N.H. and M.J. Daly). Funding and support were also provided by the University of Maryland General Clinical Research Center (M01 RR 16500), the National Institute of Diabetes and Digestive and Kidney Diseases Clinical Nutrition Research Unit of Maryland (NIH P30 DK072488), the Department of Veterans Affairs, and Veterans Affairs Medical Center Baltimore Geriatric Research, Education and Clinical Center. The Caerphilly study was funded by the UK MRC. The Caerphilly study was undertaken by the former MRC Epidemiology Unit in South Wales and was funded by the UK MRC. The data archive is maintained by the Department of Social Medicine, University of Bristol. We acknowledge use of genotype data from the British 1958 Birth Cohort DNA collection, funded by the MRC (grant G0000934) and the Wellcome Trust (grant 068545/Z/02).",
year = "2008",
month = feb,
doi = "10.1038/ng.74",
language = "English (US)",
volume = "40",
pages = "198--203",
journal = "Nature genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "2",
}