Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults

The Cardiovascular Health Study

Lucia A. Hindorff, Kenneth M. Rice, Leslie A. Lange, Paula Diehr, Indrani Halder, Jeremy D Walston, Pui Kwok, Elad Ziv, Caroline Nievergelt, Steven R. Cummings, Anne B. Newman, Russell P. Tracy, Bruce M. Psaty, Alexander P. Reiner

Research output: Contribution to journalArticle

Abstract

Common polymorphisms in the CRP gene are associated with plasma CRP levels in population-based studies, but associations with age-related events are uncertain. A previous study of CRP haplotypes in older adults was broadened to include longevity and cause-specific mortality (all-cause, noncardiovascular (non-CV), and cardiovascular (CV)). Common haplotypes were inferred from four tagSNPs in 4512 whites and five tagSNPs in 812 blacks from the Cardiovascular Health Study, a longitudinal cohort of adults over age 65. Exploratory analyses addressed early versus late mortality. CRP haplotypes were not associated with all-cause mortality or longevity overall in either population, but associations with all-cause mortality differed during early and late periods. In blacks, the haplotype tagged by 3872A (rs1205) was associated with increased risk of non-CV mortality, relative to other haplotypes (adjusted hazard ratio for each additional copy: 1.42, 95% CI: 1.07, 1.87). Relative to other haplotypes, this haplotype was associated with decreased risk of early but not decreased risk of late CV mortality in blacks; among whites, a haplotype tagged by 2667C (rs1800947) gave similar but nonsignificant findings. If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks.

Original languageEnglish (US)
Pages (from-to)922-930
Number of pages9
JournalAtherosclerosis
Volume197
Issue number2
DOIs
StatePublished - Apr 2008

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Haplotypes
Mortality
Health
Genes
Population
Longitudinal Studies

Keywords

  • Aged
  • Aging
  • C-reactive protein
  • Genetic
  • Longevity
  • Mortality
  • Polymorphism
  • Susceptibility

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults : The Cardiovascular Health Study. / Hindorff, Lucia A.; Rice, Kenneth M.; Lange, Leslie A.; Diehr, Paula; Halder, Indrani; Walston, Jeremy D; Kwok, Pui; Ziv, Elad; Nievergelt, Caroline; Cummings, Steven R.; Newman, Anne B.; Tracy, Russell P.; Psaty, Bruce M.; Reiner, Alexander P.

In: Atherosclerosis, Vol. 197, No. 2, 04.2008, p. 922-930.

Research output: Contribution to journalArticle

Hindorff, LA, Rice, KM, Lange, LA, Diehr, P, Halder, I, Walston, JD, Kwok, P, Ziv, E, Nievergelt, C, Cummings, SR, Newman, AB, Tracy, RP, Psaty, BM & Reiner, AP 2008, 'Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: The Cardiovascular Health Study', Atherosclerosis, vol. 197, no. 2, pp. 922-930. https://doi.org/10.1016/j.atherosclerosis.2007.08.012
Hindorff, Lucia A. ; Rice, Kenneth M. ; Lange, Leslie A. ; Diehr, Paula ; Halder, Indrani ; Walston, Jeremy D ; Kwok, Pui ; Ziv, Elad ; Nievergelt, Caroline ; Cummings, Steven R. ; Newman, Anne B. ; Tracy, Russell P. ; Psaty, Bruce M. ; Reiner, Alexander P. / Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults : The Cardiovascular Health Study. In: Atherosclerosis. 2008 ; Vol. 197, No. 2. pp. 922-930.
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