Common variants at 19p13 are associated with susceptibility to ovarian cancer

Kelly L. Bolton, Jonathan Tyrer, Honglin Song, Susan J. Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry-Maharaj, Eva Wozniak, Ya Yu Tsai, Joanne Weidhaas, Daniel Paik, David J. Van Den Berg, Daniel O. Stram, Celeste Leigh Pearce, Anna H. Wu, Wendy Brewster, Hoda Anton-Culver, Argyrios Ziogas, Steven A. NarodDouglas A. Levine, Stanley B. Kaye, Robert Brown, Jim Paul, James Flanagan, Weiva Sieh, Valerie McGuire, Alice S. Whittemore, Ian Campbell, Martin E. Gore, Jolanta Lissowska, Hanna P. Yang, Krzysztof Medrek, Jacek Gronwald, Jan Lubinski, Anna Jakubowska, Nhu D. Le, Linda S. Cook, Linda E. Kelemen, Angela Brook-Wilson, Leon F.A.G. Massuger, Lambertus A. Kiemeney, Katja K.H. Aben, Anne M. Van Altena, Richard Houlston, Ian Tomlinson, Rachel T. Palmieri, Patricia G. Moorman, Joellen Schildkraut, Edwin S. Iversen, Catherine Phelan, Robert A. Vierkant, Julie M. Cunningham, Ellen L. Goode, Brooke L. Fridley, Susan Kruger-Kjaer, Jan Blaeker, Estrid Hogdall, Claus Hogdall, Jenny Gross, Beth Y. Karlan, Roberta B. Ness, Robert P. Edwards, Kunle Odunsi, Kirsten B. Moyisch, Julie A. Baker, Francesmary Modugno, Tuomas Heikkinenen, Ralf Butzow, Heli Nevanlinna, Arto Leminen, Natalia Bogdanova, Natalia Antonenkova, Thilo Doerk, Peter Hillemanns, Matthias Dürst, Ingo Runnebaum, Pamela J. Thompson, Michael E. Carney, Marc T. Goodman, Galina Lurie, Shan Wang-Gohrke, Rebecca Hein, Jenny Chang-Claude, Mary Anne Rossing, Kara L. Cushing-Haugen, Jennifer Doherty, Chu Chen, Thorunn Rafnar, Soren Besenbacher, Patrick Sulem, Kari Stefansson, Michael J. Birrer, Kathryn L. Terry, Dena Hernandez, Daniel W. Cramer, Ignace Vergote, Frederic Amant, Diether Lambrechts, Evelyn Despierre, Peter A. Fasching, Matthias W. Beckmann, Falk C. Thiel, Arif B. Ekici, Xiaoqing Chen, Sharon E. Johnatty, Penelope M. Webb, Jonathan Beesley, Stephen Chanock, Montserrat Garcia-Closas, Tom Sellers, Douglas F. Easton, Andrew Berchuck, Georgia Chenevix-Trench, Paul D.P. Pharoah, Simon A. Gayther

Research output: Contribution to journalArticlepeer-review

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5×10-4 and P = 6×10-4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3×10-9 and P = 4×10-11, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

Original languageEnglish (US)
Pages (from-to)880-884
Number of pages5
JournalNature genetics
Volume42
Issue number10
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Genetics

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