@article{6898a66911164c2ab9069713490e85bb,
title = "Common sequence variants on 20q11.22 confer melanoma susceptibility",
abstract = "We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 × 10-15). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.",
author = "Brown, {Kevin M.} and Stuart MacGregor and Montgomery, {Grant W.} and Craig, {David W.} and Zhao, {Zhen Zhen} and Kelly Iyadurai and {K Henders}, Anjali and Nils Homer and Campbell, {Megan J.} and Mitchell Stark and Shane Thomas and Helen Schmid and Holland, {Elizabeth A.} and Gillanders, {Elizabeth M.} and Duffy, {David L.} and Maskiell, {Judith A.} and Jodie Jetann and Megan Ferguson and Stephan, {Dietrich A.} and Cust, {Anne E.} and David Whiteman and Adele Green and H{\aa}kan Olsson and Susana Puig and Paola Ghiorzo and Johan Hansson and Florence Demenais and Goldstein, {Alisa M.} and Gruis, {Nelleke A.} and Elder, {David E.} and Bishop, {Julia Newton} and Kefford, {Richard F.} and Giles, {Graham G.} and Armstrong, {Bruce K.} and Aitken, {Joanne F.} and Hopper, {John L.} and Martin, {Nicholas G.} and Trent, {Jeffrey M.} and Mann, {Graham J.} and Hayward, {Nicholas K.}",
note = "Funding Information: This work was supported by the National Cancer Institute (NCI) of the US National Institutes of Health (NIH) (CA88363, CA83115), the National Health and Medical Research Council of Australia (NHMRC) (380385, 389892, 496675, 402761), the Cancer Councils New South Wales, Victoria and Queensland, the Cancer Institute New South Wales, the Melanoma Research Foundation (MRF) and a charitable contribution from F. Najafi. N.K.H. and G.W.M. are supported by the NHMRC Fellowships scheme and J.L.H. is an Australia Fellow of the NHMRC. S.M. and K.M.B. are recipients of Career Development Awards from the NHMRC (496674) and MRF, respectively. K.M.B. and J.M.T. are supported by the NCI/NIH (respectively, CA109544 and CA083115; and CA109544). D.A.S. is supported by the US National Heart, Lung, and Blood Institute of the NIH (HL086528). B.K.A. is supported by the University of Sydney Medical Foundation. A.E.C. is supported by an NHMRC postdoctoral fellowship. The authors are grateful to M. Huentelman and S. Szelinger for technical assistance. The AMFS and Q-MEGA gratefully acknowledge all of their participants, the hard work of all its research interviewers and examiners, and C. Agha-Hamilton for managing the AMFS biospecimens. Q-MEGA thanks A. Baxter, M. de Nooyer, I. Gardner, D. Statham, B. Haddon, J. Palmer, B. Castellano, L. Bardsley, D. Smyth and H. Beeby for their input into project management, sample processing and database development.",
year = "2008",
month = jul,
doi = "10.1038/ng.163",
language = "English (US)",
volume = "40",
pages = "838--840",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "7",
}