Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

Jianfeng Xu, S. Lilly Zheng, Akira Komiya, Josyf C. Mychaleckyj, Sarah D. Isaacs, Baoli Chang, Aubrey R. Turner, Charles M. Ewing, Kathleen E. Wiley, Gregory A. Hawkins, Eugene R. Bleecker, Patrick C. Walsh, Deborah A. Meyers, William B. Isaacs

Research output: Contribution to journalArticle

Abstract

Rare germline mutations of macrophage scavenger receptor 1 (MSR1) gene were reported to be associated with prostate cancer risk in families with hereditary prostate cancer (HPC) and in patients with non-HPC (Xu et al. 2002). To further evaluate the role of MSR1 in prostate cancer susceptibility, at Johns Hopkins Hospital, we studied five common variants of MSR1 in 301 patients with non-HPC who underwent prostate cancer treatment and in 250 control subjects who participated in prostate cancer-screening programs and had normal digital rectal examination and PSA levels (<4 ng/ml). Significantly different allele frequencies between case subjects and control subjects were observed for each of the five variants (P value range .01-.04). Haplotype analyses provided consistent findings, with a significant difference in the haplotype frequencies from a global score test (P = .01). Because the haplotype that is associated with the increased risk for prostate cancer did not harbor any of the known rare mutations, it appears that the observed association of common variants and prostate cancer risk are independent of the effect of the known rare mutations. These results consistently suggest that MSR1 may play an important role in prostate carcinogenesis.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalAmerican journal of human genetics
Volume72
Issue number1
DOIs
StatePublished - Jan 1 2003

    Fingerprint

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Xu, J., Lilly Zheng, S., Komiya, A., Mychaleckyj, J. C., Isaacs, S. D., Chang, B., Turner, A. R., Ewing, C. M., Wiley, K. E., Hawkins, G. A., Bleecker, E. R., Walsh, P. C., Meyers, D. A., & Isaacs, W. B. (2003). Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. American journal of human genetics, 72(1), 208-212. https://doi.org/10.1086/345802