Common obesity-related genetic variants and papillary thyroid cancer risk

Cari M. Kitahara; Gila Neta; Ruth M. Pfeiffer; Deukwoo Kwon; Li Xu; Neal D. Freedman; Amy A. Hutchinson; Stephen J. Chanock; Erich M. Sturgis; Alice J. Sigurdson; Alina V. Brenner

doi:10.1158/1055-9965.EPI-12-0790

Common obesity-related genetic variants and papillary thyroid cancer risk

Cari M. Kitahara, Gila Neta, Ruth M. Pfeiffer, Deukwoo Kwon, Li Xu, Neal D. Freedman, Amy A. Hutchinson, Stephen J. Chanock, Erich M. Sturgis, Alice J. Sigurdson, Alina V. Brenner

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single-nucleotide polymorphisms (SNP). Methods: We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid cancer (PTC) cases and 444 controls of European ancestry. Logistic regression models, adjusted for attained age, year of birth, and sex were used to calculate ORs and 95% confidence intervals (CI) with SNP genotypes, coded as 0, 1, and 2 and modeled continuously to calculate P^trend. Results: Nine of 10 top-ranking SNPs (P^trend < 0.01) were located in the FTO (fat mass and obesity associated) gene region, whereas the other was located in INSR (insulin receptor). None of the associations were significant after correcting for multiple testing. Conclusions: Our data do not support an important role of obesity-related genetic polymorphisms in determining the risk of PTC. Impact: Factors other than selected genetic polymorphisms may be responsible for the observed associations between obesity and increased PTC risk.

Original language	English (US)
Pages (from-to)	2268-2271
Number of pages	4
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	21
Issue number	12
DOIs	https://doi.org/10.1158/1055-9965.EPI-12-0790
State	Published - Dec 2012
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Oncology

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title = "Common obesity-related genetic variants and papillary thyroid cancer risk",

abstract = "Background: Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single-nucleotide polymorphisms (SNP). Methods: We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid cancer (PTC) cases and 444 controls of European ancestry. Logistic regression models, adjusted for attained age, year of birth, and sex were used to calculate ORs and 95% confidence intervals (CI) with SNP genotypes, coded as 0, 1, and 2 and modeled continuously to calculate Ptrend. Results: Nine of 10 top-ranking SNPs (Ptrend < 0.01) were located in the FTO (fat mass and obesity associated) gene region, whereas the other was located in INSR (insulin receptor). None of the associations were significant after correcting for multiple testing. Conclusions: Our data do not support an important role of obesity-related genetic polymorphisms in determining the risk of PTC. Impact: Factors other than selected genetic polymorphisms may be responsible for the observed associations between obesity and increased PTC risk.",

author = "Kitahara, {Cari M.} and Gila Neta and Pfeiffer, {Ruth M.} and Deukwoo Kwon and Li Xu and Freedman, {Neal D.} and Hutchinson, {Amy A.} and Chanock, {Stephen J.} and Sturgis, {Erich M.} and Sigurdson, {Alice J.} and Brenner, {Alina V.}",

year = "2012",

month = dec,

doi = "10.1158/1055-9965.EPI-12-0790",

language = "English (US)",

volume = "21",

pages = "2268--2271",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "12",

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T1 - Common obesity-related genetic variants and papillary thyroid cancer risk

AU - Kitahara, Cari M.

AU - Neta, Gila

AU - Pfeiffer, Ruth M.

AU - Kwon, Deukwoo

AU - Xu, Li

AU - Freedman, Neal D.

AU - Hutchinson, Amy A.

AU - Chanock, Stephen J.

AU - Sturgis, Erich M.

AU - Sigurdson, Alice J.

AU - Brenner, Alina V.

PY - 2012/12

Y1 - 2012/12

N2 - Background: Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single-nucleotide polymorphisms (SNP). Methods: We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid cancer (PTC) cases and 444 controls of European ancestry. Logistic regression models, adjusted for attained age, year of birth, and sex were used to calculate ORs and 95% confidence intervals (CI) with SNP genotypes, coded as 0, 1, and 2 and modeled continuously to calculate Ptrend. Results: Nine of 10 top-ranking SNPs (Ptrend < 0.01) were located in the FTO (fat mass and obesity associated) gene region, whereas the other was located in INSR (insulin receptor). None of the associations were significant after correcting for multiple testing. Conclusions: Our data do not support an important role of obesity-related genetic polymorphisms in determining the risk of PTC. Impact: Factors other than selected genetic polymorphisms may be responsible for the observed associations between obesity and increased PTC risk.

AB - Background: Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single-nucleotide polymorphisms (SNP). Methods: We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid cancer (PTC) cases and 444 controls of European ancestry. Logistic regression models, adjusted for attained age, year of birth, and sex were used to calculate ORs and 95% confidence intervals (CI) with SNP genotypes, coded as 0, 1, and 2 and modeled continuously to calculate Ptrend. Results: Nine of 10 top-ranking SNPs (Ptrend < 0.01) were located in the FTO (fat mass and obesity associated) gene region, whereas the other was located in INSR (insulin receptor). None of the associations were significant after correcting for multiple testing. Conclusions: Our data do not support an important role of obesity-related genetic polymorphisms in determining the risk of PTC. Impact: Factors other than selected genetic polymorphisms may be responsible for the observed associations between obesity and increased PTC risk.

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Common obesity-related genetic variants and papillary thyroid cancer risk

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