Common germline polymorphisms associated with breast cancer-specific survival

Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M. Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M. Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson & 127 others Dieter Lambrechts, Caroline Weltens, Karin Leunen, Chantal van Ongeval, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru A. Muranen, Janet E. Olsen, Emily Hallberg, Celine Vachon, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Sten Cornelissen, Christopher A. Haiman, Brian E. Henderson, Frederick Schumacher, Loic Le Marchand, John L. Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C. Southey, Simon S. Cross, Malcolm W R Reed, Graham G. Giles, Roger L. Milne, Catriona McLean, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Maartje J. Hooning, Antoinette Hollestelle, John W M Martens, Ans M W van den Ouweland, Federick Marme, Andreas Schneeweiss, Rongxi Yang, Barbara Burwinkel, Jonine Figueroa, Stephen J. Chanock, Jolanta Lissowska, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Hermann Brenner, Katja Butterbach, Bernd Holleczek, Vesa Kataja, Veli Matti Kosma, Jaana M. Hartikainen, Jingmei Li, Judith S. Brand, Keith Humphreys, Peter Devilee, Robert A E M Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Filomena Ficarazzi, Matthias W. Beckmann, Alexander Hein, Arif B. Ekici, Rosemary Balleine, Kelly Anne Phillips, Javier Benitez, M. Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Anna Jakubowska, Jan Lubinski, Jacek Gronwald, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Rüdiger, Sara Margolin, Vessela Kristensen, Siljie Nord, D. Gareth Evans, Jean Abraham, Helena Earl, Christopher J. Poole, Louise Hiller, Janet A. Dunn, Sarah Bowden, Rose Yang, Daniele Campa, W. Ryan Diver, Susan M. Gapstur, Mia M. Gaudet, Susan Hankinson, Robert N. Hoover, Anika Hüsing, Rudolf Kaaks, Mitchell J. Machiela, Walter Willett, Myrto Barrdahl, Federico Canzian, Suet Feung Chin, Carlos Caldas, David J. Hunter, Sara Lindstrom, Montserrat Garcia-Closas, Fergus J. Couch, Georgia Chenevix-Trench, Arto Mannermaa, Irene L. Andrulis, Per Hall, Jenny Chang-Claude, Douglas F. Easton, Stig E. Bojesen, Angela Cox, Peter A. Fasching, Paul D P Pharoah, Marjanka K. Schmidt

Research output: Contribution to journalArticle

Abstract

Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.

Original languageEnglish (US)
Article number58
JournalBreast Cancer Research
Volume17
Issue number1
DOIs
StatePublished - Apr 22 2015
Externally publishedYes

Fingerprint

Breast Neoplasms
Genome-Wide Association Study
Disease-Free Survival
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pirie, A., Guo, Q., Kraft, P., Canisius, S., Eccles, D. M., Rahman, N., ... Schmidt, M. K. (2015). Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Research, 17(1), [58]. https://doi.org/10.1186/s13058-015-0570-7

Common germline polymorphisms associated with breast cancer-specific survival. / Pirie, Ailith; Guo, Qi; Kraft, Peter; Canisius, Sander; Eccles, Diana M.; Rahman, Nazneen; Nevanlinna, Heli; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Dunning, Alison M.; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Dieter; Weltens, Caroline; Leunen, Karin; van Ongeval, Chantal; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A.; Olsen, Janet E.; Hallberg, Emily; Vachon, Celine; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Cornelissen, Sten; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Frederick; Le Marchand, Loic; Hopper, John L.; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C.; Cross, Simon S.; Reed, Malcolm W R; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J.; Hollestelle, Antoinette; Martens, John W M; van den Ouweland, Ans M W; Marme, Federick; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Brenner, Hermann; Butterbach, Katja; Holleczek, Bernd; Kataja, Vesa; Kosma, Veli Matti; Hartikainen, Jaana M.; Li, Jingmei; Brand, Judith S.; Humphreys, Keith; Devilee, Peter; Tollenaar, Robert A E M; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Ficarazzi, Filomena; Beckmann, Matthias W.; Hein, Alexander; Ekici, Arif B.; Balleine, Rosemary; Phillips, Kelly Anne; Benitez, Javier; Zamora, M. Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Siljie; Evans, D. Gareth; Abraham, Jean; Earl, Helena; Poole, Christopher J.; Hiller, Louise; Dunn, Janet A.; Bowden, Sarah; Yang, Rose; Campa, Daniele; Diver, W. Ryan; Gapstur, Susan M.; Gaudet, Mia M.; Hankinson, Susan; Hoover, Robert N.; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J.; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet Feung; Caldas, Carlos; Hunter, David J.; Lindstrom, Sara; Garcia-Closas, Montserrat; Couch, Fergus J.; Chenevix-Trench, Georgia; Mannermaa, Arto; Andrulis, Irene L.; Hall, Per; Chang-Claude, Jenny; Easton, Douglas F.; Bojesen, Stig E.; Cox, Angela; Fasching, Peter A.; Pharoah, Paul D P; Schmidt, Marjanka K.

In: Breast Cancer Research, Vol. 17, No. 1, 58, 22.04.2015.

Research output: Contribution to journalArticle

Pirie, A, Guo, Q, Kraft, P, Canisius, S, Eccles, DM, Rahman, N, Nevanlinna, H, Chen, C, Khan, S, Tyrer, J, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Lush, M, Dunning, AM, Shah, M, Czene, K, Darabi, H, Eriksson, M, Lambrechts, D, Weltens, C, Leunen, K, van Ongeval, C, Nordestgaard, BG, Nielsen, SF, Flyger, H, Rudolph, A, Seibold, P, Flesch-Janys, D, Blomqvist, C, Aittomäki, K, Fagerholm, R, Muranen, TA, Olsen, JE, Hallberg, E, Vachon, C, Knight, JA, Glendon, G, Mulligan, AM, Broeks, A, Cornelissen, S, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Hopper, JL, Tsimiklis, H, Apicella, C, Southey, MC, Cross, SS, Reed, MWR, Giles, GG, Milne, RL, McLean, C, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Hooning, MJ, Hollestelle, A, Martens, JWM, van den Ouweland, AMW, Marme, F, Schneeweiss, A, Yang, R, Burwinkel, B, Figueroa, J, Chanock, SJ, Lissowska, J, Sawyer, EJ, Tomlinson, I, Kerin, MJ, Miller, N, Brenner, H, Butterbach, K, Holleczek, B, Kataja, V, Kosma, VM, Hartikainen, JM, Li, J, Brand, JS, Humphreys, K, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Radice, P, Peterlongo, P, Manoukian, S, Ficarazzi, F, Beckmann, MW, Hein, A, Ekici, AB, Balleine, R, Phillips, KA, Benitez, J, Zamora, MP, Perez, JIA, Menéndez, P, Jakubowska, A, Lubinski, J, Gronwald, J, Durda, K, Hamann, U, Kabisch, M, Ulmer, HU, Rüdiger, T, Margolin, S, Kristensen, V, Nord, S, Evans, DG, Abraham, J, Earl, H, Poole, CJ, Hiller, L, Dunn, JA, Bowden, S, Yang, R, Campa, D, Diver, WR, Gapstur, SM, Gaudet, MM, Hankinson, S, Hoover, RN, Hüsing, A, Kaaks, R, Machiela, MJ, Willett, W, Barrdahl, M, Canzian, F, Chin, SF, Caldas, C, Hunter, DJ, Lindstrom, S, Garcia-Closas, M, Couch, FJ, Chenevix-Trench, G, Mannermaa, A, Andrulis, IL, Hall, P, Chang-Claude, J, Easton, DF, Bojesen, SE, Cox, A, Fasching, PA, Pharoah, PDP & Schmidt, MK 2015, 'Common germline polymorphisms associated with breast cancer-specific survival', Breast Cancer Research, vol. 17, no. 1, 58. https://doi.org/10.1186/s13058-015-0570-7
Pirie, Ailith ; Guo, Qi ; Kraft, Peter ; Canisius, Sander ; Eccles, Diana M. ; Rahman, Nazneen ; Nevanlinna, Heli ; Chen, Constance ; Khan, Sofia ; Tyrer, Jonathan ; Bolla, Manjeet K. ; Wang, Qin ; Dennis, Joe ; Michailidou, Kyriaki ; Lush, Michael ; Dunning, Alison M. ; Shah, Mitul ; Czene, Kamila ; Darabi, Hatef ; Eriksson, Mikael ; Lambrechts, Dieter ; Weltens, Caroline ; Leunen, Karin ; van Ongeval, Chantal ; Nordestgaard, Børge G. ; Nielsen, Sune F. ; Flyger, Henrik ; Rudolph, Anja ; Seibold, Petra ; Flesch-Janys, Dieter ; Blomqvist, Carl ; Aittomäki, Kristiina ; Fagerholm, Rainer ; Muranen, Taru A. ; Olsen, Janet E. ; Hallberg, Emily ; Vachon, Celine ; Knight, Julia A. ; Glendon, Gord ; Mulligan, Anna Marie ; Broeks, Annegien ; Cornelissen, Sten ; Haiman, Christopher A. ; Henderson, Brian E. ; Schumacher, Frederick ; Le Marchand, Loic ; Hopper, John L. ; Tsimiklis, Helen ; Apicella, Carmel ; Southey, Melissa C. ; Cross, Simon S. ; Reed, Malcolm W R ; Giles, Graham G. ; Milne, Roger L. ; McLean, Catriona ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Hooning, Maartje J. ; Hollestelle, Antoinette ; Martens, John W M ; van den Ouweland, Ans M W ; Marme, Federick ; Schneeweiss, Andreas ; Yang, Rongxi ; Burwinkel, Barbara ; Figueroa, Jonine ; Chanock, Stephen J. ; Lissowska, Jolanta ; Sawyer, Elinor J. ; Tomlinson, Ian ; Kerin, Michael J. ; Miller, Nicola ; Brenner, Hermann ; Butterbach, Katja ; Holleczek, Bernd ; Kataja, Vesa ; Kosma, Veli Matti ; Hartikainen, Jaana M. ; Li, Jingmei ; Brand, Judith S. ; Humphreys, Keith ; Devilee, Peter ; Tollenaar, Robert A E M ; Seynaeve, Caroline ; Radice, Paolo ; Peterlongo, Paolo ; Manoukian, Siranoush ; Ficarazzi, Filomena ; Beckmann, Matthias W. ; Hein, Alexander ; Ekici, Arif B. ; Balleine, Rosemary ; Phillips, Kelly Anne ; Benitez, Javier ; Zamora, M. Pilar ; Perez, Jose Ignacio Arias ; Menéndez, Primitiva ; Jakubowska, Anna ; Lubinski, Jan ; Gronwald, Jacek ; Durda, Katarzyna ; Hamann, Ute ; Kabisch, Maria ; Ulmer, Hans Ulrich ; Rüdiger, Thomas ; Margolin, Sara ; Kristensen, Vessela ; Nord, Siljie ; Evans, D. Gareth ; Abraham, Jean ; Earl, Helena ; Poole, Christopher J. ; Hiller, Louise ; Dunn, Janet A. ; Bowden, Sarah ; Yang, Rose ; Campa, Daniele ; Diver, W. Ryan ; Gapstur, Susan M. ; Gaudet, Mia M. ; Hankinson, Susan ; Hoover, Robert N. ; Hüsing, Anika ; Kaaks, Rudolf ; Machiela, Mitchell J. ; Willett, Walter ; Barrdahl, Myrto ; Canzian, Federico ; Chin, Suet Feung ; Caldas, Carlos ; Hunter, David J. ; Lindstrom, Sara ; Garcia-Closas, Montserrat ; Couch, Fergus J. ; Chenevix-Trench, Georgia ; Mannermaa, Arto ; Andrulis, Irene L. ; Hall, Per ; Chang-Claude, Jenny ; Easton, Douglas F. ; Bojesen, Stig E. ; Cox, Angela ; Fasching, Peter A. ; Pharoah, Paul D P ; Schmidt, Marjanka K. / Common germline polymorphisms associated with breast cancer-specific survival. In: Breast Cancer Research. 2015 ; Vol. 17, No. 1.
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title = "Common germline polymorphisms associated with breast cancer-specific survival",
abstract = "Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.",
author = "Ailith Pirie and Qi Guo and Peter Kraft and Sander Canisius and Eccles, {Diana M.} and Nazneen Rahman and Heli Nevanlinna and Constance Chen and Sofia Khan and Jonathan Tyrer and Bolla, {Manjeet K.} and Qin Wang and Joe Dennis and Kyriaki Michailidou and Michael Lush and Dunning, {Alison M.} and Mitul Shah and Kamila Czene and Hatef Darabi and Mikael Eriksson and Dieter Lambrechts and Caroline Weltens and Karin Leunen and {van Ongeval}, Chantal and Nordestgaard, {B{\o}rge G.} and Nielsen, {Sune F.} and Henrik Flyger and Anja Rudolph and Petra Seibold and Dieter Flesch-Janys and Carl Blomqvist and Kristiina Aittom{\"a}ki and Rainer Fagerholm and Muranen, {Taru A.} and Olsen, {Janet E.} and Emily Hallberg and Celine Vachon and Knight, {Julia A.} and Gord Glendon and Mulligan, {Anna Marie} and Annegien Broeks and Sten Cornelissen and Haiman, {Christopher A.} and Henderson, {Brian E.} and Frederick Schumacher and {Le Marchand}, Loic and Hopper, {John L.} and Helen Tsimiklis and Carmel Apicella and Southey, {Melissa C.} and Cross, {Simon S.} and Reed, {Malcolm W R} and Giles, {Graham G.} and Milne, {Roger L.} and Catriona McLean and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Hooning, {Maartje J.} and Antoinette Hollestelle and Martens, {John W M} and {van den Ouweland}, {Ans M W} and Federick Marme and Andreas Schneeweiss and Rongxi Yang and Barbara Burwinkel and Jonine Figueroa and Chanock, {Stephen J.} and Jolanta Lissowska and Sawyer, {Elinor J.} and Ian Tomlinson and Kerin, {Michael J.} and Nicola Miller and Hermann Brenner and Katja Butterbach and Bernd Holleczek and Vesa Kataja and Kosma, {Veli Matti} and Hartikainen, {Jaana M.} and Jingmei Li and Brand, {Judith S.} and Keith Humphreys and Peter Devilee and Tollenaar, {Robert A E M} and Caroline Seynaeve and Paolo Radice and Paolo Peterlongo and Siranoush Manoukian and Filomena Ficarazzi and Beckmann, {Matthias W.} and Alexander Hein and Ekici, {Arif B.} and Rosemary Balleine and Phillips, {Kelly Anne} and Javier Benitez and Zamora, {M. Pilar} and Perez, {Jose Ignacio Arias} and Primitiva Men{\'e}ndez and Anna Jakubowska and Jan Lubinski and Jacek Gronwald and Katarzyna Durda and Ute Hamann and Maria Kabisch and Ulmer, {Hans Ulrich} and Thomas R{\"u}diger and Sara Margolin and Vessela Kristensen and Siljie Nord and Evans, {D. Gareth} and Jean Abraham and Helena Earl and Poole, {Christopher J.} and Louise Hiller and Dunn, {Janet A.} and Sarah Bowden and Rose Yang and Daniele Campa and Diver, {W. Ryan} and Gapstur, {Susan M.} and Gaudet, {Mia M.} and Susan Hankinson and Hoover, {Robert N.} and Anika H{\"u}sing and Rudolf Kaaks and Machiela, {Mitchell J.} and Walter Willett and Myrto Barrdahl and Federico Canzian and Chin, {Suet Feung} and Carlos Caldas and Hunter, {David J.} and Sara Lindstrom and Montserrat Garcia-Closas and Couch, {Fergus J.} and Georgia Chenevix-Trench and Arto Mannermaa and Andrulis, {Irene L.} and Per Hall and Jenny Chang-Claude and Easton, {Douglas F.} and Bojesen, {Stig E.} and Angela Cox and Fasching, {Peter A.} and Pharoah, {Paul D P} and Schmidt, {Marjanka K.}",
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TY - JOUR

T1 - Common germline polymorphisms associated with breast cancer-specific survival

AU - Pirie, Ailith

AU - Guo, Qi

AU - Kraft, Peter

AU - Canisius, Sander

AU - Eccles, Diana M.

AU - Rahman, Nazneen

AU - Nevanlinna, Heli

AU - Chen, Constance

AU - Khan, Sofia

AU - Tyrer, Jonathan

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Dennis, Joe

AU - Michailidou, Kyriaki

AU - Lush, Michael

AU - Dunning, Alison M.

AU - Shah, Mitul

AU - Czene, Kamila

AU - Darabi, Hatef

AU - Eriksson, Mikael

AU - Lambrechts, Dieter

AU - Weltens, Caroline

AU - Leunen, Karin

AU - van Ongeval, Chantal

AU - Nordestgaard, Børge G.

AU - Nielsen, Sune F.

AU - Flyger, Henrik

AU - Rudolph, Anja

AU - Seibold, Petra

AU - Flesch-Janys, Dieter

AU - Blomqvist, Carl

AU - Aittomäki, Kristiina

AU - Fagerholm, Rainer

AU - Muranen, Taru A.

AU - Olsen, Janet E.

AU - Hallberg, Emily

AU - Vachon, Celine

AU - Knight, Julia A.

AU - Glendon, Gord

AU - Mulligan, Anna Marie

AU - Broeks, Annegien

AU - Cornelissen, Sten

AU - Haiman, Christopher A.

AU - Henderson, Brian E.

AU - Schumacher, Frederick

AU - Le Marchand, Loic

AU - Hopper, John L.

AU - Tsimiklis, Helen

AU - Apicella, Carmel

AU - Southey, Melissa C.

AU - Cross, Simon S.

AU - Reed, Malcolm W R

AU - Giles, Graham G.

AU - Milne, Roger L.

AU - McLean, Catriona

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Hooning, Maartje J.

AU - Hollestelle, Antoinette

AU - Martens, John W M

AU - van den Ouweland, Ans M W

AU - Marme, Federick

AU - Schneeweiss, Andreas

AU - Yang, Rongxi

AU - Burwinkel, Barbara

AU - Figueroa, Jonine

AU - Chanock, Stephen J.

AU - Lissowska, Jolanta

AU - Sawyer, Elinor J.

AU - Tomlinson, Ian

AU - Kerin, Michael J.

AU - Miller, Nicola

AU - Brenner, Hermann

AU - Butterbach, Katja

AU - Holleczek, Bernd

AU - Kataja, Vesa

AU - Kosma, Veli Matti

AU - Hartikainen, Jaana M.

AU - Li, Jingmei

AU - Brand, Judith S.

AU - Humphreys, Keith

AU - Devilee, Peter

AU - Tollenaar, Robert A E M

AU - Seynaeve, Caroline

AU - Radice, Paolo

AU - Peterlongo, Paolo

AU - Manoukian, Siranoush

AU - Ficarazzi, Filomena

AU - Beckmann, Matthias W.

AU - Hein, Alexander

AU - Ekici, Arif B.

AU - Balleine, Rosemary

AU - Phillips, Kelly Anne

AU - Benitez, Javier

AU - Zamora, M. Pilar

AU - Perez, Jose Ignacio Arias

AU - Menéndez, Primitiva

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Gronwald, Jacek

AU - Durda, Katarzyna

AU - Hamann, Ute

AU - Kabisch, Maria

AU - Ulmer, Hans Ulrich

AU - Rüdiger, Thomas

AU - Margolin, Sara

AU - Kristensen, Vessela

AU - Nord, Siljie

AU - Evans, D. Gareth

AU - Abraham, Jean

AU - Earl, Helena

AU - Poole, Christopher J.

AU - Hiller, Louise

AU - Dunn, Janet A.

AU - Bowden, Sarah

AU - Yang, Rose

AU - Campa, Daniele

AU - Diver, W. Ryan

AU - Gapstur, Susan M.

AU - Gaudet, Mia M.

AU - Hankinson, Susan

AU - Hoover, Robert N.

AU - Hüsing, Anika

AU - Kaaks, Rudolf

AU - Machiela, Mitchell J.

AU - Willett, Walter

AU - Barrdahl, Myrto

AU - Canzian, Federico

AU - Chin, Suet Feung

AU - Caldas, Carlos

AU - Hunter, David J.

AU - Lindstrom, Sara

AU - Garcia-Closas, Montserrat

AU - Couch, Fergus J.

AU - Chenevix-Trench, Georgia

AU - Mannermaa, Arto

AU - Andrulis, Irene L.

AU - Hall, Per

AU - Chang-Claude, Jenny

AU - Easton, Douglas F.

AU - Bojesen, Stig E.

AU - Cox, Angela

AU - Fasching, Peter A.

AU - Pharoah, Paul D P

AU - Schmidt, Marjanka K.

PY - 2015/4/22

Y1 - 2015/4/22

N2 - Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.

AB - Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.

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U2 - 10.1186/s13058-015-0570-7

DO - 10.1186/s13058-015-0570-7

M3 - Article

VL - 17

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 1

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ER -