Common genetic variants in candidate genes and risk of familial lymphoid malignancies

Xueying Liang, Neil Caporaso, Mary Lou McMaster, David Ng, Ola Landgren, Meredith Yeager, Stephen Chanock, Lynn R. Goldin

Research output: Contribution to journalArticle

Abstract

Familial aggregation, linkage and case-control studies support the role of germline genes in the aetiology of lymphoid malignancies. To further examine the role of genetic variation underlying susceptibility, we analysed 1536 single nucleotide polymorphisms in 152 genes involved in apoptosis, DNA repair, immune response and oxidative stress pathways among a unique sample of 165 unrelated familial cases including patients with chronic lymphocytic leukaemia (CLL), Waldenström macroglobulinaemia (WM) and Hodgkin lymphoma (HL), and 107 spouse controls. We confirmed previous studies showing a polymorphism in the IL10 promoter (rs1800890/-3575T>A) to be associated with non-Hodgkin lymphoma, as this allele was found to be associated with both CLL and WM. We also confirmed the role of IL6 variation to be associated with HL. Polymorphisms in TNFSF10 were associated with both CLL and WM. Future replication and functional studies are needed to clarify the role of these genetic variants. Finally, our data further support the close association of WM and CLL.

Original languageEnglish (US)
Pages (from-to)418-423
Number of pages6
JournalBritish journal of haematology
Volume146
Issue number4
DOIs
StatePublished - Aug 1 2009

Keywords

  • Association
  • Candidate genes
  • Chronic lymphocytic leukaemia
  • Familial
  • Lymphoid malignancies

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Liang, X., Caporaso, N., McMaster, M. L., Ng, D., Landgren, O., Yeager, M., Chanock, S., & Goldin, L. R. (2009). Common genetic variants in candidate genes and risk of familial lymphoid malignancies. British journal of haematology, 146(4), 418-423. https://doi.org/10.1111/j.1365-2141.2009.07790.x