Common genetic variants and risk for non-Hodgkin lymphoma and adult T-cell lymphoma/leukemia in Jamaica

Sophia S. Wang, J. Daniel Carreon, Barrie Hanchard, Stephen Chanock, Michie Hisada

Research output: Contribution to journalArticle

Abstract

We evaluated whether risk of non-Hodgkin lymphoma (NHL), particularly adult T-cell leukemia/lymphoma (ATL) related to human T-lymphotropic virus (HTLV) infection was associated with 63 single nucleotide polymorphisms (SNPs) from 38 candidate genes. The 395 NHL cases registered in Jamaica were matched by age, sex, calendar-year and HTLV serostatus to 309 controls from the same population. Interleukin 13 (IL13) Ex4198A>G SNP (rs20541) was associated with decreased NHL risk (ORAG/AA = 0.62,95% CI = 0.44-0.87, p = 0.006), as was vascular cell adhesion molecule-1, VCAM1 Ex91149G>A SNP (rs1041163) (OR CT = 0.77, 95% CI = 0.54-1.10, ORCC=0.35, 95% CI = 0.16-0.76, p-trend = 0.007). Both results were stronger in analyses restricted to ATL cases and HTLV-positive controls, suggesting a role for these genes in ATL etiology (IL13 ORAG/AA = 0.54, 95% CI = 0.36-0.84, p = 0.005; VCAM1 ORCT = 0.65, 95% CI = 0.42-1.01, ORCC = 0.20, 95% CI = 0.08-0.54, p-trend = 0.001). Confirmation of these results in Caribbean and other populations is needed.

Original languageEnglish (US)
Pages (from-to)1479-1482
Number of pages4
JournalInternational Journal of Cancer
Volume125
Issue number6
DOIs
StatePublished - Sep 15 2009

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Keywords

  • ATL
  • HTLV-I
  • Jamaica
  • NHL
  • SNP

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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