Common genetic variants and risk for HPV persistence and progression to cervical cancer

Sophia S. Wang, Paula Gonzalez, Kai Yu, Carolina Porras, Qizhai Li, Mahboobeh Safaeian, Ana Cecilia Rodriguez, Mark E. Sherman, Concepcion Bratti, Mark Schiffman, Sholom Wacholder, Robert D. Burk, Rolando Herrero, Stephen J. Chanock, Allan Hildesheim

Research output: Contribution to journalArticle

Abstract

HPV infrequently persists and progresses to cervical cancer. We examined host genetic factors hypothesized to play a role in determining which subset of individuals infected with oncogenic human papillomavirus (HPV) have persistent infection and further develop cervical pre-cancer/cancer compared to the majority of infected individuals who will clear infection. We evaluated 7140 tag single nucleotide polymorphisms (SNPs) from 305 candidate genes hypothesized to be involved in DNA repair, viral infection and cell entry in 416 cervical intraepithelial neoplasia 3 (CIN3)/cancer cases, 356 HPV persistent women (median: 25 months), and 425 random controls (RC) from the 10,049 women Guanacaste Costa Rica Natural History study. We used logistic regression to compute odds ratios and p-trend for CIN3/cancer and HPV persistence in relation to SNP genotypes and haplotypes (adjusted for age). We obtained pathway and gene-level summary of associations by computing the adaptive combination of p-values. Genes/regions statistically significantly associated with CIN3/cancer included the viral infection and cell entry genes 2′,5′ oligoadenylate synthetase gene 3 (OAS3), sulfatase 1 (SULF1), and interferon gamma (IFNG); the DNA repair genes deoxyuridine triphosphate (DUT), dosage suppressor of mck 1 homolog (DMC1), and general transcription factor IIH, polypeptide 3 (GTF2H4); and the EVER1 and EVER2 genes (p

Original languageEnglish (US)
Article numbere8667
JournalPLoS One
Volume5
Issue number1
DOIs
StatePublished - Jan 13 2010
Externally publishedYes

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uterine cervical neoplasms
Papillomaviridae
Uterine Cervical Neoplasms
Genes
neoplasms
Cervical Intraepithelial Neoplasia
genes
Virus Diseases
Polymorphism
DNA Repair
DNA repair
Single Nucleotide Polymorphism
Neoplasms
infection
Transcription Factor TFIIH
single nucleotide polymorphism
Repair
Nucleotides
General Transcription Factors
Sulfatases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Wang, S. S., Gonzalez, P., Yu, K., Porras, C., Li, Q., Safaeian, M., ... Hildesheim, A. (2010). Common genetic variants and risk for HPV persistence and progression to cervical cancer. PLoS One, 5(1), [e8667]. https://doi.org/10.1371/journal.pone.0008667

Common genetic variants and risk for HPV persistence and progression to cervical cancer. / Wang, Sophia S.; Gonzalez, Paula; Yu, Kai; Porras, Carolina; Li, Qizhai; Safaeian, Mahboobeh; Rodriguez, Ana Cecilia; Sherman, Mark E.; Bratti, Concepcion; Schiffman, Mark; Wacholder, Sholom; Burk, Robert D.; Herrero, Rolando; Chanock, Stephen J.; Hildesheim, Allan.

In: PLoS One, Vol. 5, No. 1, e8667, 13.01.2010.

Research output: Contribution to journalArticle

Wang, SS, Gonzalez, P, Yu, K, Porras, C, Li, Q, Safaeian, M, Rodriguez, AC, Sherman, ME, Bratti, C, Schiffman, M, Wacholder, S, Burk, RD, Herrero, R, Chanock, SJ & Hildesheim, A 2010, 'Common genetic variants and risk for HPV persistence and progression to cervical cancer', PLoS One, vol. 5, no. 1, e8667. https://doi.org/10.1371/journal.pone.0008667
Wang, Sophia S. ; Gonzalez, Paula ; Yu, Kai ; Porras, Carolina ; Li, Qizhai ; Safaeian, Mahboobeh ; Rodriguez, Ana Cecilia ; Sherman, Mark E. ; Bratti, Concepcion ; Schiffman, Mark ; Wacholder, Sholom ; Burk, Robert D. ; Herrero, Rolando ; Chanock, Stephen J. ; Hildesheim, Allan. / Common genetic variants and risk for HPV persistence and progression to cervical cancer. In: PLoS One. 2010 ; Vol. 5, No. 1.
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