Common data elements for traumatic brain injury: Recommendations from the biospecimens and biomarkers working group

Geoffrey T. Manley, Ramon Diaz-Arrastia, Mary Brophy, Doortje Engel, Clay Goodman, Katrina Gwinn, Timothy D. Veenstra, Geoffrey Ling, Andrew K. Ottens, Frank Tortella, Ronald L. Hayes

Research output: Contribution to journalReview article

Abstract

Recent advances in genomics, proteomics, and biotechnology have provided unprecedented opportunities for translational research and personalized medicine. Human biospecimens and biofluids represent an important resource from which molecular data can be generated to detect and classify injury and to identify molecular mechanisms and therapeutic targets. To date, there has been considerable variability in biospecimen and biofluid collection, storage, and processing in traumatic brain injury (TBI) studies. To realize the full potential of this important resource, standardization and adoption of best practice guidelines are required to insure the quality and consistency of these specimens. The aim of the Biospecimens and Biomarkers Working Group was to provide recommendations for core data elements for TBI research and develop best practice guidelines to standardize the quality and accessibility of these specimens. Consensus recommendations were developed through interactions with focus groups and input from stakeholders participating in the interagency workshop on Standardization of Data Collection in TBI and Psychological Health held in Washington, DC, in March 2009. With the adoption of these standards and best practices, future investigators will be able to obtain data across multiple studies with reduced costs and effort and accelerate the progress of genomic, proteomic, and metabolomic research in TBI.

Original languageEnglish (US)
Pages (from-to)1667-1672
Number of pages6
JournalArchives of Physical Medicine and Rehabilitation
Volume91
Issue number11
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

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Practice Guidelines
Biomarkers
Translational Medical Research
Proteomics
Precision Medicine
Metabolomics
Biotechnology
Genomics
Focus Groups
Research
Research Personnel
Traumatic Brain Injury
Common Data Elements
Psychology
Education
Costs and Cost Analysis
Health
Wounds and Injuries
Therapeutics

Keywords

  • Biological Markers
  • Brain Injuries
  • Rehabilitation

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Cite this

Common data elements for traumatic brain injury : Recommendations from the biospecimens and biomarkers working group. / Manley, Geoffrey T.; Diaz-Arrastia, Ramon; Brophy, Mary; Engel, Doortje; Goodman, Clay; Gwinn, Katrina; Veenstra, Timothy D.; Ling, Geoffrey; Ottens, Andrew K.; Tortella, Frank; Hayes, Ronald L.

In: Archives of Physical Medicine and Rehabilitation, Vol. 91, No. 11, 01.11.2010, p. 1667-1672.

Research output: Contribution to journalReview article

Manley, GT, Diaz-Arrastia, R, Brophy, M, Engel, D, Goodman, C, Gwinn, K, Veenstra, TD, Ling, G, Ottens, AK, Tortella, F & Hayes, RL 2010, 'Common data elements for traumatic brain injury: Recommendations from the biospecimens and biomarkers working group', Archives of Physical Medicine and Rehabilitation, vol. 91, no. 11, pp. 1667-1672. https://doi.org/10.1016/j.apmr.2010.05.018
Manley, Geoffrey T. ; Diaz-Arrastia, Ramon ; Brophy, Mary ; Engel, Doortje ; Goodman, Clay ; Gwinn, Katrina ; Veenstra, Timothy D. ; Ling, Geoffrey ; Ottens, Andrew K. ; Tortella, Frank ; Hayes, Ronald L. / Common data elements for traumatic brain injury : Recommendations from the biospecimens and biomarkers working group. In: Archives of Physical Medicine and Rehabilitation. 2010 ; Vol. 91, No. 11. pp. 1667-1672.
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