Commentary: IL-4 and IL-13 receptors and signaling

Sarah M. McCormick, Nicola M. Heller

Research output: Contribution to journalArticle

Abstract

Interleukin (IL)-4 and IL-13 were discovered approximately 30. years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.

Original languageEnglish (US)
Pages (from-to)38-50
Number of pages13
JournalCytokine
Volume75
Issue number1
DOIs
StatePublished - Sep 1 2015

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Keywords

  • Interleukin-13
  • Interleukin-4
  • Receptor
  • Regulation
  • Singling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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