Commentary: IL-4 and IL-13 receptors and signaling

Sarah M. McCormick; Nicola M. Heller

doi:10.1016/j.cyto.2015.05.023

Commentary: IL-4 and IL-13 receptors and signaling

Sarah M. McCormick, Nicola M. Heller

School of Medicine

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Interleukin (IL)-4 and IL-13 were discovered approximately 30. years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.

Original language	English (US)
Pages (from-to)	38-50
Number of pages	13
Journal	Cytokine
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/j.cyto.2015.05.023
State	Published - Sep 1 2015

Keywords

Interleukin-13
Interleukin-4
Receptor
Regulation
Singling

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

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10.1016/j.cyto.2015.05.023

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Commentary: IL-4 and IL-13 receptors and signaling

Abstract

Keywords

ASJC Scopus subject areas

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