Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

Barbara Burtness; Shanthi Marur; Julie E. Bauman; Erica A. Golemis; Ranee Mehra; Steven J. Cohen

doi:10.1126/scisignal.2003734

Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

Barbara Burtness, Shanthi Marur, Julie E. Bauman, Erica A. Golemis, Ranee Mehra, Steven J. Cohen

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.

Original language	English (US)
Article number	lc5
Journal	Science signaling
Volume	5
Issue number	254
DOIs	https://doi.org/10.1126/scisignal.2003734
State	Published - Dec 11 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1126/scisignal.2003734

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abstract = "Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.",

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AU - Burtness, Barbara

AU - Marur, Shanthi

AU - Bauman, Julie E.

AU - Golemis, Erica A.

AU - Mehra, Ranee

AU - Cohen, Steven J.

PY - 2012/12/11

Y1 - 2012/12/11

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AB - Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.

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Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

Abstract

ASJC Scopus subject areas

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