Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

Barbara Burtness, Shanthi Marur, Julie E. Bauman, Erica A. Golemis, Ranee Mehra, Steven J. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.

Original languageEnglish (US)
Article numberlc5
JournalScience signaling
Volume5
Issue number254
DOIs
StatePublished - Dec 11 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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