Combining necrosis and platelet markers for perfecting myocardial infarction rule out: How close are we?

Girish V. Nair, Paul A. Gurbel, Sergey Y. Fuzaylov, Christopher J. Davis, E. Magnus Ohman, Raymond D. Bahr, Robert H. Christensen, Victor L. Serebruany

Research output: Contribution to journalArticle

Abstract

Each year, at least 5 million patients in the United States present to hospital emergency departments with the complaint of chest pain, and more than 10% of them will be diagnosed with acute myocardial infarction. One of the foremost tasks of the emergency department physician is to avoid unnecessary admissions and concomitantly to minimize the number of patients discharged home inappropriately. Currently available diagnostic tools, including the electrocardiogram and myocardial markers, have several shortcomings, including low specificity, and delayed sensitivity for the timely detection of myocardial necrosis. Therefore, the search for better methods of rapidly identifying patients with unstable coronary syndromes is one of the utmost priorities of modern emergency medicine. Available biochemical diagnostic tools are discussed in this review, focusing on the potential benefits of combining myocardial necrosis markers with indicators of platelet activation. It is hypothesized that such a combined approach may be more powerful in myocardial infarction risk stratification than separate marker determination. Copyright (C) 2000 S. Kerger AG, Basel.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalCardiology
Volume93
Issue number1-2
StatePublished - 2000

Fingerprint

Necrosis
Blood Platelets
Myocardial Infarction
Hospital Emergency Service
Modern 1601-history
Emergency Medicine
Hospital Departments
Platelet Activation
Chest Pain
Electrocardiography
Physicians
Sensitivity and Specificity

Keywords

  • Acute myocardial infarction
  • Chest pain
  • Emergency department
  • Necrosis markers
  • Platelets

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nair, G. V., Gurbel, P. A., Fuzaylov, S. Y., Davis, C. J., Ohman, E. M., Bahr, R. D., ... Serebruany, V. L. (2000). Combining necrosis and platelet markers for perfecting myocardial infarction rule out: How close are we? Cardiology, 93(1-2), 50-55.

Combining necrosis and platelet markers for perfecting myocardial infarction rule out : How close are we? / Nair, Girish V.; Gurbel, Paul A.; Fuzaylov, Sergey Y.; Davis, Christopher J.; Ohman, E. Magnus; Bahr, Raymond D.; Christensen, Robert H.; Serebruany, Victor L.

In: Cardiology, Vol. 93, No. 1-2, 2000, p. 50-55.

Research output: Contribution to journalArticle

Nair, GV, Gurbel, PA, Fuzaylov, SY, Davis, CJ, Ohman, EM, Bahr, RD, Christensen, RH & Serebruany, VL 2000, 'Combining necrosis and platelet markers for perfecting myocardial infarction rule out: How close are we?', Cardiology, vol. 93, no. 1-2, pp. 50-55.
Nair GV, Gurbel PA, Fuzaylov SY, Davis CJ, Ohman EM, Bahr RD et al. Combining necrosis and platelet markers for perfecting myocardial infarction rule out: How close are we? Cardiology. 2000;93(1-2):50-55.
Nair, Girish V. ; Gurbel, Paul A. ; Fuzaylov, Sergey Y. ; Davis, Christopher J. ; Ohman, E. Magnus ; Bahr, Raymond D. ; Christensen, Robert H. ; Serebruany, Victor L. / Combining necrosis and platelet markers for perfecting myocardial infarction rule out : How close are we?. In: Cardiology. 2000 ; Vol. 93, No. 1-2. pp. 50-55.
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