Combining immunotherapy with radiation for the treatment of glioblastoma

Kevin K.H. Chow, Wendy Hara, Michael Lim, Gordon Li

Research output: Contribution to journalReview articlepeer-review

Abstract

Glioblastoma is a devastating cancer with universally poor outcomes in spite of current standard multimodal therapy. Immunotherapy is an attractive new treatment modality given its potential for exquisite specificity and its favorable side effect profile; however, clinical trials of immunotherapy in GBM have thus far shown modest benefit. Optimally combining radiation with immunotherapy may be the key to unlocking the potential of both therapies given the evidence that radiation can enhance anti-tumor immunity. Here we review this evidence and discuss considerations for combined therapy.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalJournal of neuro-oncology
Volume123
Issue number3
DOIs
StatePublished - Jul 23 2015

Keywords

  • Glioblastoma
  • Immunosuppression
  • Immunotherapy
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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