Combining hidden Markov models for comparing the dynamics of multiple sleep electroencephalograms

Roland Langrock, Bruce J. Swihart, Brian S Caffo, Naresh M Punjabi, Ciprian M Crainiceanu

Research output: Contribution to journalArticle

Abstract

In this manuscript, we consider methods for the analysis of populations of electroencephalogram signals during sleep for the study of sleep disorders using hidden Markov models (HMMs). Notably, we propose an easily implemented method for simultaneously modeling multiple time series that involve large amounts of data. We apply these methods to study sleep-disordered breathing (SDB) in the Sleep Heart Health Study (SHHS), a landmark study of SDB and cardiovascular consequences. We use the entire, longitudinally collected, SHHS cohort to develop HMM population parameters, which we then apply to obtain subject-specific Markovian predictions. From these predictions, we create several indices of interest, such as transition frequencies between latent states. Our HMM analysis of electroencephalogram signals uncovers interesting findings regarding differences in brain activity during sleep between those with and without SDB. These findings include stability of the percent time spent in HMM latent states across matched diseased and non-diseased groups and differences in the rate of transitioning.

Original languageEnglish (US)
Pages (from-to)3342-3356
Number of pages15
JournalStatistics in Medicine
Volume32
Issue number19
DOIs
StatePublished - Aug 30 2013

Fingerprint

Sleep
Markov Model
Electroencephalography
Sleep Apnea Syndromes
Health
Population
Cohort Studies
Multiple Time Series
Population parameter
Cohort Study
Electroencephalogram
Prediction
Brain
Landmarks
Model Analysis
Percent
Disorder
Entire
Modeling

Keywords

  • Dirichlet distribution
  • Fourier power spectrum
  • Independent mixture
  • Markov chain
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

Cite this

Combining hidden Markov models for comparing the dynamics of multiple sleep electroencephalograms. / Langrock, Roland; Swihart, Bruce J.; Caffo, Brian S; Punjabi, Naresh M; Crainiceanu, Ciprian M.

In: Statistics in Medicine, Vol. 32, No. 19, 30.08.2013, p. 3342-3356.

Research output: Contribution to journalArticle

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