Combining generative models for multifocal glioma segmentation and registration

Dongjin Kwon, Russell T. Shinohara, Hamed Akbari, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we propose a new method for simultaneously segmenting brain scans of glioma patients and registering these scans to a normal atlas. Performing joint segmentation and registration for brain tumors is very challenging when tumors include multifocal masses and have complex shapes with heterogeneous textures. Our approach grows tumors for each mass from multiple seed points using a tumor growth model and modifies a normal atlas into one with tumors and edema using the combined results of grown tumors. We also generate a tumor shape prior via the random walk with restart, utilizing multiple tumor seeds as initial foreground information. We then incorporate this shape prior into an EM framework which estimates the mapping between the modified atlas and the scans, posteriors for each tissue labels, and the tumor growth model parameters. We apply our method to the BRATS 2013 leaderboard dataset to evaluate segmentation performance. Our method shows the best performance among all participants.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - 17th International Conference, Proceedings
PublisherSpringer Verlag
Pages763-770
Number of pages8
EditionPART 1
ISBN (Print)9783319104034
DOIs
StatePublished - 2014
Event17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014 - Boston, MA, United States
Duration: Sep 14 2014Sep 18 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume8673 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014
CountryUnited States
CityBoston, MA
Period9/14/149/18/14

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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