TY - JOUR
T1 - Combining functional imaging with brain stimulation in Parkinson's disease
AU - Obeso, Ignacio
AU - Ray, Nicola J.
AU - Antonelli, Francesca
AU - Cho, Sang Soo
AU - Strafella, Antonio P.
N1 - Funding Information:
Declaration of interest: A.P.S. is supported by the Canadian Institutes of Health Research (MOP-110962), the Edmond J. Safra Philanthropic Foundation and the Canada Research Chair Program.The authors alone are responsible for the content and writing of the paper.
PY - 2011/10
Y1 - 2011/10
N2 - Brain stimulation techniques such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS) constitute promising clinical and research tools to investigate neural mechanisms underlying neurological and psychiatric diseases. They have enormous potential in modifying brain activity and subsequent function. However, it is still a matter of debate how either of these stimulation approaches operates to produce the clinical outcomes observed in patients. The combination of these techniques with functional neuroimaging is contributing significantly to disentangle the mechanisms through which brain stimulation affects neuronal activity and related networks. In the present review we outline the research done to date on the effects of DBS and TMS on motor, cognition and behaviour in Parkinson's disease (PD) with particular emphasis on neuroimaging.
AB - Brain stimulation techniques such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS) constitute promising clinical and research tools to investigate neural mechanisms underlying neurological and psychiatric diseases. They have enormous potential in modifying brain activity and subsequent function. However, it is still a matter of debate how either of these stimulation approaches operates to produce the clinical outcomes observed in patients. The combination of these techniques with functional neuroimaging is contributing significantly to disentangle the mechanisms through which brain stimulation affects neuronal activity and related networks. In the present review we outline the research done to date on the effects of DBS and TMS on motor, cognition and behaviour in Parkinson's disease (PD) with particular emphasis on neuroimaging.
UR - http://www.scopus.com/inward/record.url?scp=84855229539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855229539&partnerID=8YFLogxK
U2 - 10.3109/09540261.2011.621414
DO - 10.3109/09540261.2011.621414
M3 - Article
C2 - 22200136
AN - SCOPUS:84855229539
SN - 0954-0261
VL - 23
SP - 467
EP - 475
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 5
ER -