Combined vascular and extracellular pH imaging of solid tumors

Z. M. Bhujwalla, D. Artemov, P. Ballesteros, S. Cerdan, R. J. Gillies, M. Solaiyappan

Research output: Contribution to journalArticlepeer-review

Abstract

The unique physiological environment of solid tumors, frequently characterized by areas of poor flow, hypoxia, high lactate and low extracellular pH (pHe), influences vascularization, invasion and metastasis. Thus, vascularization and the physiological and metabolic environment play permissive (and conversely preventive) roles in invasion and metastasis. By using a multi-parametric approach of combined vascular and spectroscopic imaging, we can begin to evaluate which combinations of vascular, metabolic and physiological regions in a solid tumor represent the highest 'metastatic threat'. Here, we present measurements of pHe, vascular volume and permeability from colocalized regions within a solid tumor. These studies were performed for a group of metastatic (MDA-MB-231) and non-metastatic (MCF-7) human breast cancer xenografts. In this study, we have demonstrated the feasibility of such an approach, and presented methods of analyses to detect differences in patterns of combined parameters obtained from spatially co-registered regions in a solid tumor.

Original languageEnglish (US)
Pages (from-to)114-119
Number of pages6
JournalNMR in biomedicine
Volume15
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Breast cancer
  • Extracellular pH
  • Metastasis
  • Spectroscopic and vascular imaging
  • Vascularization

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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