Three children with terminal cancer, ages 7, 9, and 14 years, who exhibited severe symptoms of depression and anxiety, were treated with a combination of low dose amitriptyline (1–2 mg/kg/24 hours) and haloperidol (0.05–0.10 mg/kg/24 hours). Anxiety decreased, mood improved, vegetative symptoms were alleviated, and requirements for narcotic analgesia decreased within 1 week of inception of pharmacotherapy. Symptoms reemerged in two patients when the medications were discontinued. Importantly, the psychopharmaco-logic interventions allowed the patients and their families to deal with the dynamic issues involved in chronic illness and death and dying.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the American Academy of Child Psychiatry|
|State||Published - 1985|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Psychiatry and Mental health