Combined Use of Tricyclic Antidepressants and Neuroleptics in the Management of Terminally 111 Children: A Report on Three Cases

MOHAMMAD MAISAMI, BARBARA H. SOHMER, JOSEPH T. COYLE

Research output: Contribution to journalArticlepeer-review

Abstract

Three children with terminal cancer, ages 7, 9, and 14 years, who exhibited severe symptoms of depression and anxiety, were treated with a combination of low dose amitriptyline (1–2 mg/kg/24 hours) and haloperidol (0.05–0.10 mg/kg/24 hours). Anxiety decreased, mood improved, vegetative symptoms were alleviated, and requirements for narcotic analgesia decreased within 1 week of inception of pharmacotherapy. Symptoms reemerged in two patients when the medications were discontinued. Importantly, the psychopharmaco-logic interventions allowed the patients and their families to deal with the dynamic issues involved in chronic illness and death and dying.

Original languageEnglish (US)
Pages (from-to)487-489
Number of pages3
JournalJournal of the American Academy of Child Psychiatry
Volume24
Issue number4
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health

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