Combined use of tricyclic antidepressants and neuroleptics in the management of terminally III children

A report on three cases

Mohammad Maisami, Barbara H. Sohmer, Joseph T. Coyle

Research output: Contribution to journalArticle

Abstract

Three children with terminal cancer, ages 7, 9, and 14 years, who exhibited severe symptoms of depression and anxiety, were treated with a combination of low dose amitriptyline (1-2 mg/kg/24 hours) and haloperidol (0.05-0.10 mg/kg/24 hours). Anxiety decreased, mood improved, vegetative symptoms were alleviated, and requirements for narcotic analgesia decreased within 1 week of inception of pharmacotherapy. Symptoms reemerged in two patients when the medications were discontinued. Importantly, the psychopharmaco-logic interventions allowed the patients and their families to deal with the dynamic issues involved in chronic illness and death and dying.

Original languageEnglish (US)
Pages (from-to)487-489
Number of pages3
JournalJournal of the American Academy of Child Psychiatry
Volume24
Issue number4
StatePublished - 1985

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Tricyclic Antidepressive Agents
Antipsychotic Agents
Anxiety
Amitriptyline
Narcotics
Haloperidol
Analgesia
Chronic Disease
Depression
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health

Cite this

Combined use of tricyclic antidepressants and neuroleptics in the management of terminally III children : A report on three cases. / Maisami, Mohammad; Sohmer, Barbara H.; Coyle, Joseph T.

In: Journal of the American Academy of Child Psychiatry, Vol. 24, No. 4, 1985, p. 487-489.

Research output: Contribution to journalArticle

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