Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants

Yin Yao Shugart, Andrew Collins

Research output: Contribution to journalArticle

Abstract

Through a literature search, we identified a total of 59 nuclear families with Hodgkin's disease (HD). The affected individuals in these families were HLA haplotyped. To evaluate the role of HLA-linked determinants of HD and investigate the mode of inheritance of familial HD, a combined segregation and linkage analysis was performed, together with a semi-parametric analysis of sib pairs. Amongst single locus models, a general single locus model showed no improvement over an additive model. However, a two locus additive model gave the best overall fit and a lod score of 3.55. We conclude that HD is most likely to be determined by both an HLA-associated major gene and other non-HLA genetic factors together with environmental effects.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalEuropean Journal of Human Genetics
Volume8
Issue number6
DOIs
StatePublished - Jun 2000

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Keywords

  • EBV
  • HLA
  • Hodgkin's disease
  • Linkage
  • Sib pairs

ASJC Scopus subject areas

  • Genetics(clinical)

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