Combined opiate/adrenergic receptor blockade enhances squirrel monkey vocalization

James C O Harris, John D. Newman

Research output: Contribution to journalArticle

Abstract

This study provides evidence for the interaction between opiate and noradrenergic neuronal systems on primate vocal behavior. The rate of twitters produced by adult squirrel monkeys was increased in an additive or synergistic manner by the combined administration of the α2 adrenergic antagonist yohimbine and the opiate antagonist naloxone. Similar effects were not demonstrated on the isolation call. In addition, the drug combination led to an increase of autonomic symptoms. The anatomical localization of these findings and mechanism for the production of increased twitters requires further investigation.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume31
Issue number1
DOIs
StatePublished - 1988

Fingerprint

Opiate Alkaloids
Saimiri
Opioid Receptors
Adrenergic Receptors
Adrenergic Antagonists
Yohimbine
Drug Combinations
Naloxone
Primates
Sciuridae

Keywords

  • Anxiety
  • Isolation call
  • Opiate
  • Separation anxiety
  • Squirrel monkey
  • Vocalization
  • α Adrenergic

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Combined opiate/adrenergic receptor blockade enhances squirrel monkey vocalization. / Harris, James C O; Newman, John D.

In: Pharmacology Biochemistry and Behavior, Vol. 31, No. 1, 1988, p. 223-226.

Research output: Contribution to journalArticle

@article{c22a1ddfaecd49b2a33b095a5174b0b1,
title = "Combined opiate/adrenergic receptor blockade enhances squirrel monkey vocalization",
abstract = "This study provides evidence for the interaction between opiate and noradrenergic neuronal systems on primate vocal behavior. The rate of twitters produced by adult squirrel monkeys was increased in an additive or synergistic manner by the combined administration of the α2 adrenergic antagonist yohimbine and the opiate antagonist naloxone. Similar effects were not demonstrated on the isolation call. In addition, the drug combination led to an increase of autonomic symptoms. The anatomical localization of these findings and mechanism for the production of increased twitters requires further investigation.",
keywords = "Anxiety, Isolation call, Opiate, Separation anxiety, Squirrel monkey, Vocalization, α Adrenergic",
author = "Harris, {James C O} and Newman, {John D.}",
year = "1988",
doi = "10.1016/0091-3057(88)90337-1",
language = "English (US)",
volume = "31",
pages = "223--226",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Combined opiate/adrenergic receptor blockade enhances squirrel monkey vocalization

AU - Harris, James C O

AU - Newman, John D.

PY - 1988

Y1 - 1988

N2 - This study provides evidence for the interaction between opiate and noradrenergic neuronal systems on primate vocal behavior. The rate of twitters produced by adult squirrel monkeys was increased in an additive or synergistic manner by the combined administration of the α2 adrenergic antagonist yohimbine and the opiate antagonist naloxone. Similar effects were not demonstrated on the isolation call. In addition, the drug combination led to an increase of autonomic symptoms. The anatomical localization of these findings and mechanism for the production of increased twitters requires further investigation.

AB - This study provides evidence for the interaction between opiate and noradrenergic neuronal systems on primate vocal behavior. The rate of twitters produced by adult squirrel monkeys was increased in an additive or synergistic manner by the combined administration of the α2 adrenergic antagonist yohimbine and the opiate antagonist naloxone. Similar effects were not demonstrated on the isolation call. In addition, the drug combination led to an increase of autonomic symptoms. The anatomical localization of these findings and mechanism for the production of increased twitters requires further investigation.

KW - Anxiety

KW - Isolation call

KW - Opiate

KW - Separation anxiety

KW - Squirrel monkey

KW - Vocalization

KW - α Adrenergic

UR - http://www.scopus.com/inward/record.url?scp=0024161077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024161077&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(88)90337-1

DO - 10.1016/0091-3057(88)90337-1

M3 - Article

C2 - 2908063

AN - SCOPUS:0024161077

VL - 31

SP - 223

EP - 226

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 1

ER -