Abstract
Utilizing combined liquid chromatography-tandem mass spectrometry (LC-MS/MS) as the analytical method, we have demonstrated a ten to sixtyfold excess of lysophosphatidyl choline containing hexacosanoic acid (26:0) in dried blood spots on a filter paper matrix from 25 male patients with X-linked adrenoleukodystrophy and nine patients with peroxisome biogenesis disorders compared to 19 controls. There was no overlap between normal subjects versus affected subjects.
Original language | English (US) |
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Pages (from-to) | 185-187 |
Number of pages | 3 |
Journal | Molecular genetics and metabolism |
Volume | 89 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2006 |
Keywords
- Adrenoleukodystrophy
- Electrospray ionization (ESI)
- Liquid chromatography-tandem mass spectrometry
- Lysophosphatidyl choline
- Multiple reaction monitoring (MRM)
- Newborn screening
- Quantitation
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Biology
- Genetics
- Endocrinology