Abstract
Three hundred and twenty-seven consecutive in-vitro fertilization (IVF) cycles in which luteal-phase leuprolide had been given were ranked according to the number of pre-ovulatory oocytes obtained (1-5, 6-10, >10). Excess pre-embryos were cryopreserved at the pronuclear stage and later transferred Into monitored natural cycles on the day after ovulation. The results indicate that the retrieval of large numbers of pre-ovulatory oocytes (>10) has a small negative impact on oocyte quality as judged by fertilization rates (4% lower). However, implantation was not impaired compared to lower levels of retrieval in either the original IVF or subsequent cryo-thaw cycles. Overall, despite the small reduction in fertilization rate, the retrieval of many pre ovulatory oocytes has produced a 'take-home baby rate' per stimulation cycle of 28.3% when 6-10 pre-ovulatory oocytes were retrieved and 41.5% when >10 were retrieved: even higher rates are anticipated when the remaining cryo preserved pre-embryos are ultimately thawed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 284-289 |
| Number of pages | 6 |
| Journal | Human Reproduction |
| Volume | 6 |
| Issue number | 2 |
| State | Published - Feb 1991 |
| Externally published | Yes |
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Keywords
- Cryopreservation
- Implantation
- IVF
- Oocytes
- Pregnancy
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Reproductive Medicine
- Obstetrics and Gynecology
- Rehabilitation
- Physiology
- Developmental Biology
Cite this
Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome. / Toner, James P.; Brzyski, Robert G.; Oehninger, Sergio; Veeck, Lucinda L.; Simonetti, Simonetta; Muasher, Suheil J.
In: Human Reproduction, Vol. 6, No. 2, 02.1991, p. 284-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome
AU - Toner, James P.
AU - Brzyski, Robert G.
AU - Oehninger, Sergio
AU - Veeck, Lucinda L.
AU - Simonetti, Simonetta
AU - Muasher, Suheil J.
PY - 1991/2
Y1 - 1991/2
N2 - Three hundred and twenty-seven consecutive in-vitro fertilization (IVF) cycles in which luteal-phase leuprolide had been given were ranked according to the number of pre-ovulatory oocytes obtained (1-5, 6-10, >10). Excess pre-embryos were cryopreserved at the pronuclear stage and later transferred Into monitored natural cycles on the day after ovulation. The results indicate that the retrieval of large numbers of pre-ovulatory oocytes (>10) has a small negative impact on oocyte quality as judged by fertilization rates (4% lower). However, implantation was not impaired compared to lower levels of retrieval in either the original IVF or subsequent cryo-thaw cycles. Overall, despite the small reduction in fertilization rate, the retrieval of many pre ovulatory oocytes has produced a 'take-home baby rate' per stimulation cycle of 28.3% when 6-10 pre-ovulatory oocytes were retrieved and 41.5% when >10 were retrieved: even higher rates are anticipated when the remaining cryo preserved pre-embryos are ultimately thawed.
AB - Three hundred and twenty-seven consecutive in-vitro fertilization (IVF) cycles in which luteal-phase leuprolide had been given were ranked according to the number of pre-ovulatory oocytes obtained (1-5, 6-10, >10). Excess pre-embryos were cryopreserved at the pronuclear stage and later transferred Into monitored natural cycles on the day after ovulation. The results indicate that the retrieval of large numbers of pre-ovulatory oocytes (>10) has a small negative impact on oocyte quality as judged by fertilization rates (4% lower). However, implantation was not impaired compared to lower levels of retrieval in either the original IVF or subsequent cryo-thaw cycles. Overall, despite the small reduction in fertilization rate, the retrieval of many pre ovulatory oocytes has produced a 'take-home baby rate' per stimulation cycle of 28.3% when 6-10 pre-ovulatory oocytes were retrieved and 41.5% when >10 were retrieved: even higher rates are anticipated when the remaining cryo preserved pre-embryos are ultimately thawed.
KW - Cryopreservation
KW - Implantation
KW - IVF
KW - Oocytes
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0025758895&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025758895&partnerID=8YFLogxK
M3 - Article
C2 - 1905316
AN - SCOPUS:0025758895
VL - 6
SP - 284
EP - 289
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 2
ER -