Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome

James P. Toner, Robert G. Brzyski, Sergio Oehninger, Lucinda L. Veeck, Simonetta Simonetti, Suheil J. Muasher

Research output: Contribution to journalArticle

Abstract

Three hundred and twenty-seven consecutive in-vitro fertilization (IVF) cycles in which luteal-phase leuprolide had been given were ranked according to the number of pre-ovulatory oocytes obtained (1-5, 6-10, >10). Excess pre-embryos were cryopreserved at the pronuclear stage and later transferred Into monitored natural cycles on the day after ovulation. The results indicate that the retrieval of large numbers of pre-ovulatory oocytes (>10) has a small negative impact on oocyte quality as judged by fertilization rates (4% lower). However, implantation was not impaired compared to lower levels of retrieval in either the original IVF or subsequent cryo-thaw cycles. Overall, despite the small reduction in fertilization rate, the retrieval of many pre ovulatory oocytes has produced a 'take-home baby rate' per stimulation cycle of 28.3% when 6-10 pre-ovulatory oocytes were retrieved and 41.5% when >10 were retrieved: even higher rates are anticipated when the remaining cryo preserved pre-embryos are ultimately thawed.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalHuman Reproduction
Volume6
Issue number2
StatePublished - Feb 1991
Externally publishedYes

Fingerprint

Cryopreservation
In Vitro Fertilization
Oocyte
Fertilization in Vitro
Oocytes
Cycle
Retrieval
Fertilization
Embryo
Embryonic Structures
Ovulation
Leuprolide
Implantation
Luteal Phase
Excess
Consecutive
In vitro fertilization

Keywords

  • Cryopreservation
  • Implantation
  • IVF
  • Oocytes
  • Pregnancy

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Rehabilitation
  • Physiology
  • Developmental Biology

Cite this

Toner, J. P., Brzyski, R. G., Oehninger, S., Veeck, L. L., Simonetti, S., & Muasher, S. J. (1991). Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome. Human Reproduction, 6(2), 284-289.

Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome. / Toner, James P.; Brzyski, Robert G.; Oehninger, Sergio; Veeck, Lucinda L.; Simonetti, Simonetta; Muasher, Suheil J.

In: Human Reproduction, Vol. 6, No. 2, 02.1991, p. 284-289.

Research output: Contribution to journalArticle

Toner, JP, Brzyski, RG, Oehninger, S, Veeck, LL, Simonetti, S & Muasher, SJ 1991, 'Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome', Human Reproduction, vol. 6, no. 2, pp. 284-289.
Toner JP, Brzyski RG, Oehninger S, Veeck LL, Simonetti S, Muasher SJ. Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome. Human Reproduction. 1991 Feb;6(2):284-289.
Toner, James P. ; Brzyski, Robert G. ; Oehninger, Sergio ; Veeck, Lucinda L. ; Simonetti, Simonetta ; Muasher, Suheil J. / Combined impact of the number of pre-ovulatory oocytes and cryopreservation on IVF outcome. In: Human Reproduction. 1991 ; Vol. 6, No. 2. pp. 284-289.
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