Combined hepatic resection and radio-frequency ablation for patients with colorectal cancer liver metastasis

A viable option for patients with a large number of tumors

Toshiro Masuda, Georgios Antonios Margonis, Nikolaos Andreatos, Jaeyun Wang, Samuel Warner, Muhammad Bilal Mirza, Anastasios Angelou, Christos Damaskos, Nikolaos Garmpis, Kazunari Sasaki, Jin He, Katsunori Imai, Yo Ichi Yamashita, Christopher Wolfgang, Hideo Baba, Matthew J Weiss

Research output: Contribution to journalArticle

Abstract

Background/Aim: Radiofrequency ablation (RFA) is thought to result in inferior prognosis than hepatic resection among patients with colorectal liver metastasis (CRLM). However, resection plus RFA may be an option for patients with a large number of tumors (≥4 liver lesions) and borderline resectability. Materials and Methods: A total of 717 patients with CRLM who underwent hepatic resection +/- RFA at two tertiary institutions between 09/01/2000-12/01/2015 were eligible for inclusion in this study. Results: Among patients with <4 lesions (n=568), OS in the resection + RFA group (n=48) was significantly worse than in the resection alone group (n=520) (5-year OS: 34.4 % versus 58.9%, p=0.007). Conversely, in patients with ≥4 lesions, OS in the resection + RFA (n=68) and resection alone(n=81) groups were not significantly different (5-year OS: 31.9% versus 34.1%, p=0.48). In patients with <4 lesions, carcinoembryonic antigen (CEA) ≥30 ng/ml, extrahepatic metastasis, preoperative chemotherapy and resection + RFA were independently associated with poor prognosis. Interestingly, in patients with ≥4 lesions, positive primary lymph nodes, KRAS mutation, CEA ≥30 ng/ml and extrahepatic metastasis were independent predictors of poor prognosis; however, the combination of hepatic resection with RFA was not associated with worse survival (p=0.93). Conclusion: Although surgeons should always strive for R0 resection when feasible, combined resection and RFA may be a viable alternative for CRLM patients with a large number of tumors.

Original languageEnglish (US)
Pages (from-to)6353-6360
Number of pages8
JournalAnticancer Research
Volume38
Issue number11
DOIs
StatePublished - Nov 1 2018

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Liver Neoplasms
Radio
Colorectal Neoplasms
Neoplasm Metastasis
Liver
Neoplasms
Carcinoembryonic Antigen
Lymph Nodes
Drug Therapy
Mutation
Survival

Keywords

  • Colorectal cancer liver metastasis
  • Hepatic resection
  • Radio-frequency ablation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Combined hepatic resection and radio-frequency ablation for patients with colorectal cancer liver metastasis : A viable option for patients with a large number of tumors. / Masuda, Toshiro; Margonis, Georgios Antonios; Andreatos, Nikolaos; Wang, Jaeyun; Warner, Samuel; Mirza, Muhammad Bilal; Angelou, Anastasios; Damaskos, Christos; Garmpis, Nikolaos; Sasaki, Kazunari; He, Jin; Imai, Katsunori; Yamashita, Yo Ichi; Wolfgang, Christopher; Baba, Hideo; Weiss, Matthew J.

In: Anticancer Research, Vol. 38, No. 11, 01.11.2018, p. 6353-6360.

Research output: Contribution to journalArticle

Masuda, T, Margonis, GA, Andreatos, N, Wang, J, Warner, S, Mirza, MB, Angelou, A, Damaskos, C, Garmpis, N, Sasaki, K, He, J, Imai, K, Yamashita, YI, Wolfgang, C, Baba, H & Weiss, MJ 2018, 'Combined hepatic resection and radio-frequency ablation for patients with colorectal cancer liver metastasis: A viable option for patients with a large number of tumors', Anticancer Research, vol. 38, no. 11, pp. 6353-6360. https://doi.org/10.21873/anticanres.12993
Masuda, Toshiro ; Margonis, Georgios Antonios ; Andreatos, Nikolaos ; Wang, Jaeyun ; Warner, Samuel ; Mirza, Muhammad Bilal ; Angelou, Anastasios ; Damaskos, Christos ; Garmpis, Nikolaos ; Sasaki, Kazunari ; He, Jin ; Imai, Katsunori ; Yamashita, Yo Ichi ; Wolfgang, Christopher ; Baba, Hideo ; Weiss, Matthew J. / Combined hepatic resection and radio-frequency ablation for patients with colorectal cancer liver metastasis : A viable option for patients with a large number of tumors. In: Anticancer Research. 2018 ; Vol. 38, No. 11. pp. 6353-6360.
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abstract = "Background/Aim: Radiofrequency ablation (RFA) is thought to result in inferior prognosis than hepatic resection among patients with colorectal liver metastasis (CRLM). However, resection plus RFA may be an option for patients with a large number of tumors (≥4 liver lesions) and borderline resectability. Materials and Methods: A total of 717 patients with CRLM who underwent hepatic resection +/- RFA at two tertiary institutions between 09/01/2000-12/01/2015 were eligible for inclusion in this study. Results: Among patients with <4 lesions (n=568), OS in the resection + RFA group (n=48) was significantly worse than in the resection alone group (n=520) (5-year OS: 34.4 {\%} versus 58.9{\%}, p=0.007). Conversely, in patients with ≥4 lesions, OS in the resection + RFA (n=68) and resection alone(n=81) groups were not significantly different (5-year OS: 31.9{\%} versus 34.1{\%}, p=0.48). In patients with <4 lesions, carcinoembryonic antigen (CEA) ≥30 ng/ml, extrahepatic metastasis, preoperative chemotherapy and resection + RFA were independently associated with poor prognosis. Interestingly, in patients with ≥4 lesions, positive primary lymph nodes, KRAS mutation, CEA ≥30 ng/ml and extrahepatic metastasis were independent predictors of poor prognosis; however, the combination of hepatic resection with RFA was not associated with worse survival (p=0.93). Conclusion: Although surgeons should always strive for R0 resection when feasible, combined resection and RFA may be a viable alternative for CRLM patients with a large number of tumors.",
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T1 - Combined hepatic resection and radio-frequency ablation for patients with colorectal cancer liver metastasis

T2 - A viable option for patients with a large number of tumors

AU - Masuda, Toshiro

AU - Margonis, Georgios Antonios

AU - Andreatos, Nikolaos

AU - Wang, Jaeyun

AU - Warner, Samuel

AU - Mirza, Muhammad Bilal

AU - Angelou, Anastasios

AU - Damaskos, Christos

AU - Garmpis, Nikolaos

AU - Sasaki, Kazunari

AU - He, Jin

AU - Imai, Katsunori

AU - Yamashita, Yo Ichi

AU - Wolfgang, Christopher

AU - Baba, Hideo

AU - Weiss, Matthew J

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background/Aim: Radiofrequency ablation (RFA) is thought to result in inferior prognosis than hepatic resection among patients with colorectal liver metastasis (CRLM). However, resection plus RFA may be an option for patients with a large number of tumors (≥4 liver lesions) and borderline resectability. Materials and Methods: A total of 717 patients with CRLM who underwent hepatic resection +/- RFA at two tertiary institutions between 09/01/2000-12/01/2015 were eligible for inclusion in this study. Results: Among patients with <4 lesions (n=568), OS in the resection + RFA group (n=48) was significantly worse than in the resection alone group (n=520) (5-year OS: 34.4 % versus 58.9%, p=0.007). Conversely, in patients with ≥4 lesions, OS in the resection + RFA (n=68) and resection alone(n=81) groups were not significantly different (5-year OS: 31.9% versus 34.1%, p=0.48). In patients with <4 lesions, carcinoembryonic antigen (CEA) ≥30 ng/ml, extrahepatic metastasis, preoperative chemotherapy and resection + RFA were independently associated with poor prognosis. Interestingly, in patients with ≥4 lesions, positive primary lymph nodes, KRAS mutation, CEA ≥30 ng/ml and extrahepatic metastasis were independent predictors of poor prognosis; however, the combination of hepatic resection with RFA was not associated with worse survival (p=0.93). Conclusion: Although surgeons should always strive for R0 resection when feasible, combined resection and RFA may be a viable alternative for CRLM patients with a large number of tumors.

AB - Background/Aim: Radiofrequency ablation (RFA) is thought to result in inferior prognosis than hepatic resection among patients with colorectal liver metastasis (CRLM). However, resection plus RFA may be an option for patients with a large number of tumors (≥4 liver lesions) and borderline resectability. Materials and Methods: A total of 717 patients with CRLM who underwent hepatic resection +/- RFA at two tertiary institutions between 09/01/2000-12/01/2015 were eligible for inclusion in this study. Results: Among patients with <4 lesions (n=568), OS in the resection + RFA group (n=48) was significantly worse than in the resection alone group (n=520) (5-year OS: 34.4 % versus 58.9%, p=0.007). Conversely, in patients with ≥4 lesions, OS in the resection + RFA (n=68) and resection alone(n=81) groups were not significantly different (5-year OS: 31.9% versus 34.1%, p=0.48). In patients with <4 lesions, carcinoembryonic antigen (CEA) ≥30 ng/ml, extrahepatic metastasis, preoperative chemotherapy and resection + RFA were independently associated with poor prognosis. Interestingly, in patients with ≥4 lesions, positive primary lymph nodes, KRAS mutation, CEA ≥30 ng/ml and extrahepatic metastasis were independent predictors of poor prognosis; however, the combination of hepatic resection with RFA was not associated with worse survival (p=0.93). Conclusion: Although surgeons should always strive for R0 resection when feasible, combined resection and RFA may be a viable alternative for CRLM patients with a large number of tumors.

KW - Colorectal cancer liver metastasis

KW - Hepatic resection

KW - Radio-frequency ablation

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