Combined heart-kidney transplant improves post-transplant survival compared with isolated heart transplant in recipients with reduced glomerular filtration rate: Analysis of 593 combined heart-kidney transplants from the United Network Organ Sharing Database

Tara Karamlou, Karl F. Welke, D. Michael McMullan, Gordon A. Cohen, Jill Gelow, Frederick A. Tibayan, James M. Mudd, Matthew S. Slater, Howard K. Song

Research output: Contribution to journalArticle

Abstract

Objective: Criteria for simultaneous heart-kidney transplant (HKTx) recipients are unclear. We characterized the evolution of combined HKTx in the United States over time compared with isolated heart transplantation (HTx) and determined factors maximizing post-transplant survival. We focused on whether a threshold estimated glomerular filtration rate (eGFR) could be identified that justified combined transplantation. Methods: A supplemented United Network Organ Sharing Dataset identified HTx and HKTx recipients from 2000 to 2010. eGFR was calculated for HTx and recipients were grouped into eGFR quintiles. Time-related mortality was compared among recipients, with multivariable factors sought using Cox proportional hazard regression models. Results: We identified 26,183 HTx recipients, of whom 593 were HKTx recipients. HTx increased modestly over time (3.6%), whereas prevalence of HKTx increased dramatically (147%). Risk-unadjusted survival was similar among HTx recipients (8.4 ± 0.04 years) and HKTx recipients (7.7 ± 0.2 years) (P =.76). Isolated HTx recipients in the lowest eGFR quintile had decreased survival (P

Original languageEnglish (US)
JournalJournal of Thoracic and Cardiovascular Surgery
Volume147
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Fingerprint

Glomerular Filtration Rate
Databases
Transplants
Kidney
Survival
Heart Transplantation
Proportional Hazards Models
Transplantation
Mortality
Transplant Recipients

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Combined heart-kidney transplant improves post-transplant survival compared with isolated heart transplant in recipients with reduced glomerular filtration rate : Analysis of 593 combined heart-kidney transplants from the United Network Organ Sharing Database. / Karamlou, Tara; Welke, Karl F.; McMullan, D. Michael; Cohen, Gordon A.; Gelow, Jill; Tibayan, Frederick A.; Mudd, James M.; Slater, Matthew S.; Song, Howard K.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 147, No. 1, 01.2014.

Research output: Contribution to journalArticle

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abstract = "Objective: Criteria for simultaneous heart-kidney transplant (HKTx) recipients are unclear. We characterized the evolution of combined HKTx in the United States over time compared with isolated heart transplantation (HTx) and determined factors maximizing post-transplant survival. We focused on whether a threshold estimated glomerular filtration rate (eGFR) could be identified that justified combined transplantation. Methods: A supplemented United Network Organ Sharing Dataset identified HTx and HKTx recipients from 2000 to 2010. eGFR was calculated for HTx and recipients were grouped into eGFR quintiles. Time-related mortality was compared among recipients, with multivariable factors sought using Cox proportional hazard regression models. Results: We identified 26,183 HTx recipients, of whom 593 were HKTx recipients. HTx increased modestly over time (3.6{\%}), whereas prevalence of HKTx increased dramatically (147{\%}). Risk-unadjusted survival was similar among HTx recipients (8.4 ± 0.04 years) and HKTx recipients (7.7 ± 0.2 years) (P =.76). Isolated HTx recipients in the lowest eGFR quintile had decreased survival (P",
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AU - Welke, Karl F.

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AU - Gelow, Jill

AU - Tibayan, Frederick A.

AU - Mudd, James M.

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AU - Song, Howard K.

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