Combined Effect of High Low-Density Lipoprotein Cholesterol and Metabolic Syndrome on Subclinical Coronary Atherosclerosis in White Men Without Clinical Evidence of Myocardial Ischemia

Catherine Y. Campbell, Khurram Nasir, Ammar Sarwar, Romeu S. Meneghelo, Jose A M Carvalho, Roger S Blumenthal, Raul D. Santos

Research output: Contribution to journalArticle

Abstract

High low-density lipoprotein (LDL) cholesterol and the presence of metabolic syndrome (MS) are established risk factors for clinical and subclinical cardiovascular disease (CVD). However, the relative contribution to CVD risk of MS and high LDL cholesterol is not well defined. Therefore, the aim was assess the relative risk for the presence of coronary artery calcification (CAC) with metabolic syndrome (MS) compared with that of moderate or high LDL cholesterol. A total of 440 consecutive asymptomatic men (mean age 46 ± 7 years, range 29 to 65) presenting for CVD risk stratification were studied. MS was defined using National Cholesterol Education Program Adult Treatment Panel III criteria (n = 112; 24%). Moderate LDL cholesterol was defined as 130 to 159 mg/dl, and high LDL cholesterol as ≥160 mg/dl (n = 76; 17%). Overall, CAC was observed in 190 men (40%). The prevalence of CAC >0 was lowest in MS-negative men with LDL cholesterol 0 was highest in MS-positive men combined with high LDL cholesterol. In conclusion, these results suggest that the risk of CAC in asymptomatic men with moderate or high LDL cholesterol is magnified in persons with MS.

Original languageEnglish (US)
Pages (from-to)840-843
Number of pages4
JournalThe American Journal of Cardiology
Volume100
Issue number5
DOIs
StatePublished - Sep 1 2007

Fingerprint

LDL Cholesterol
HDL Cholesterol
Myocardial Ischemia
Coronary Artery Disease
Coronary Vessels
Cardiovascular Diseases
Cholesterol
Education

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Combined Effect of High Low-Density Lipoprotein Cholesterol and Metabolic Syndrome on Subclinical Coronary Atherosclerosis in White Men Without Clinical Evidence of Myocardial Ischemia. / Campbell, Catherine Y.; Nasir, Khurram; Sarwar, Ammar; Meneghelo, Romeu S.; Carvalho, Jose A M; Blumenthal, Roger S; Santos, Raul D.

In: The American Journal of Cardiology, Vol. 100, No. 5, 01.09.2007, p. 840-843.

Research output: Contribution to journalArticle

Campbell, Catherine Y. ; Nasir, Khurram ; Sarwar, Ammar ; Meneghelo, Romeu S. ; Carvalho, Jose A M ; Blumenthal, Roger S ; Santos, Raul D. / Combined Effect of High Low-Density Lipoprotein Cholesterol and Metabolic Syndrome on Subclinical Coronary Atherosclerosis in White Men Without Clinical Evidence of Myocardial Ischemia. In: The American Journal of Cardiology. 2007 ; Vol. 100, No. 5. pp. 840-843.
@article{fc8f97967e574438bc127d92b1ea7a60,
title = "Combined Effect of High Low-Density Lipoprotein Cholesterol and Metabolic Syndrome on Subclinical Coronary Atherosclerosis in White Men Without Clinical Evidence of Myocardial Ischemia",
abstract = "High low-density lipoprotein (LDL) cholesterol and the presence of metabolic syndrome (MS) are established risk factors for clinical and subclinical cardiovascular disease (CVD). However, the relative contribution to CVD risk of MS and high LDL cholesterol is not well defined. Therefore, the aim was assess the relative risk for the presence of coronary artery calcification (CAC) with metabolic syndrome (MS) compared with that of moderate or high LDL cholesterol. A total of 440 consecutive asymptomatic men (mean age 46 ± 7 years, range 29 to 65) presenting for CVD risk stratification were studied. MS was defined using National Cholesterol Education Program Adult Treatment Panel III criteria (n = 112; 24{\%}). Moderate LDL cholesterol was defined as 130 to 159 mg/dl, and high LDL cholesterol as ≥160 mg/dl (n = 76; 17{\%}). Overall, CAC was observed in 190 men (40{\%}). The prevalence of CAC >0 was lowest in MS-negative men with LDL cholesterol 0 was highest in MS-positive men combined with high LDL cholesterol. In conclusion, these results suggest that the risk of CAC in asymptomatic men with moderate or high LDL cholesterol is magnified in persons with MS.",
author = "Campbell, {Catherine Y.} and Khurram Nasir and Ammar Sarwar and Meneghelo, {Romeu S.} and Carvalho, {Jose A M} and Blumenthal, {Roger S} and Santos, {Raul D.}",
year = "2007",
month = "9",
day = "1",
doi = "10.1016/j.amjcard.2007.04.018",
language = "English (US)",
volume = "100",
pages = "840--843",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Combined Effect of High Low-Density Lipoprotein Cholesterol and Metabolic Syndrome on Subclinical Coronary Atherosclerosis in White Men Without Clinical Evidence of Myocardial Ischemia

AU - Campbell, Catherine Y.

AU - Nasir, Khurram

AU - Sarwar, Ammar

AU - Meneghelo, Romeu S.

AU - Carvalho, Jose A M

AU - Blumenthal, Roger S

AU - Santos, Raul D.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - High low-density lipoprotein (LDL) cholesterol and the presence of metabolic syndrome (MS) are established risk factors for clinical and subclinical cardiovascular disease (CVD). However, the relative contribution to CVD risk of MS and high LDL cholesterol is not well defined. Therefore, the aim was assess the relative risk for the presence of coronary artery calcification (CAC) with metabolic syndrome (MS) compared with that of moderate or high LDL cholesterol. A total of 440 consecutive asymptomatic men (mean age 46 ± 7 years, range 29 to 65) presenting for CVD risk stratification were studied. MS was defined using National Cholesterol Education Program Adult Treatment Panel III criteria (n = 112; 24%). Moderate LDL cholesterol was defined as 130 to 159 mg/dl, and high LDL cholesterol as ≥160 mg/dl (n = 76; 17%). Overall, CAC was observed in 190 men (40%). The prevalence of CAC >0 was lowest in MS-negative men with LDL cholesterol 0 was highest in MS-positive men combined with high LDL cholesterol. In conclusion, these results suggest that the risk of CAC in asymptomatic men with moderate or high LDL cholesterol is magnified in persons with MS.

AB - High low-density lipoprotein (LDL) cholesterol and the presence of metabolic syndrome (MS) are established risk factors for clinical and subclinical cardiovascular disease (CVD). However, the relative contribution to CVD risk of MS and high LDL cholesterol is not well defined. Therefore, the aim was assess the relative risk for the presence of coronary artery calcification (CAC) with metabolic syndrome (MS) compared with that of moderate or high LDL cholesterol. A total of 440 consecutive asymptomatic men (mean age 46 ± 7 years, range 29 to 65) presenting for CVD risk stratification were studied. MS was defined using National Cholesterol Education Program Adult Treatment Panel III criteria (n = 112; 24%). Moderate LDL cholesterol was defined as 130 to 159 mg/dl, and high LDL cholesterol as ≥160 mg/dl (n = 76; 17%). Overall, CAC was observed in 190 men (40%). The prevalence of CAC >0 was lowest in MS-negative men with LDL cholesterol 0 was highest in MS-positive men combined with high LDL cholesterol. In conclusion, these results suggest that the risk of CAC in asymptomatic men with moderate or high LDL cholesterol is magnified in persons with MS.

UR - http://www.scopus.com/inward/record.url?scp=34547997693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547997693&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2007.04.018

DO - 10.1016/j.amjcard.2007.04.018

M3 - Article

VL - 100

SP - 840

EP - 843

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 5

ER -