@article{a41e59ae48854042a524c3809c217156,
title = "Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q",
abstract = "Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the original genotype data provides benefits of increased power and control over sources of heterogeneity that outweigh the difficulty and potential pitfalls of the implementation. We conducted a combined analysis using the original genotype data from 11 BP genomewide linkage scans comprising 5,179 individuals from 1,067 families. Heterogeneity among studies was minimized in our analyses by using uniform methods of analysis and a common, standardized marker map and was assessed using novel methods developed for meta-analysis of genome scans. To date, this collaboration is the largest and most comprehensive analysis of linkage samples involving a psychiatric disorder. We demonstrate that combining original genome-scan data is a powerful approach for the elucidation of linkage regions underlying complex disease. Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches.",
author = "McQueen, {Matthew B.} and B. Devlin and Faraone, {Stephen V.} and Nimgaonkar, {Vishwajit L.} and Pamela Sklar and Smoller, {Jordan W.} and Jamra, {Rami Abou} and Margot Albus and Bacanu, {Silviu Alin} and Miron Baron and Barrett, {Thomas B.} and Wade Berrettini and Deborah Blacker and William Byerley and Sven Cichon and Willam Coryell and Nick Craddock and Daly, {Mark J.} and DePaulo, {J. Raymond} and Edenberg, {Howard J.} and Tatiana Foroud and Michael Gill and Gilliam, {T. Conrad} and Marian Hamshere and Ian Jones and Lisa Jones and Juo, {Suh Hang} and Kelsoe, {John R.} and David Lambert and Christoph Lange and Bernard Lerer and Jianjun Liu and Wolfgang Maier and MacKinnon, {James D.} and McInnis, {Melvin G.} and McMahon, {Francis J.} and Murphy, {Dennis L.} and N{\"o}then, {Markus M.} and Nurnberger, {John I.} and Pato, {Carlos N.} and Pato, {Michele T.} and Potash, {James B.} and Peter Propping and Pulver, {Ann E.} and Rice, {John P.} and Marcella Rietschel and William Scheftner and Johannes Schumacher and Ricardo Segurado and {Van Steen}, Kristel and Weiting Xie and Zandi, {Peter P.} and Laird, {Nan M.}",
note = "Funding Information: The principal investigators of the Genetic Determinants of Bipolar Disorder Project (B.D., S.V.F., N.M.L., V.L.N., P.S., and J.W.S) and M.B.M. were supported by NIMH grants R01-MH063445, MH63420, and MH0667288; M.B.M. was additionally supported by NIMH grant T32-MH017119. Collection of data and biomaterials from the Bonn study was supported by the Deutsche Forschungsgemeinschaft. Data and biomaterials from the four NIMH studies were collected in four projects that participated in the NIMH Bipolar Disorder Genetics Initiative. In 1991–1998, the principal investigators and coinvestigators were: J.I.N., Marvin J. Miller, H.J.E., T.F., and Elizabeth S. Bowman, grant U01 MH46282 to Indiana University, Indianapolis; Theodore Reich, Allison Goate, and J.P.R., grant U01 MH46280 to Washington University, St. Louis; J.R.D., Sylvia Simpson, and Colin Stine, grant U01 MH46274 to Johns Hopkins University, Baltimore; Elliot Gershon, Diane Kazuba, and Elizabeth Maxwell, NIMH Intramural Research Program, Clinical Neurogenetics Branch, Bethesda. Data and biomaterials were collected as part of 10 projects that participated in the NIMH Bipolar Disorder Genetics Initiative. In 1999–2003, the principal investigators and coinvestigators were: J.I.N., Marvin J. Miller, Elizabeth S. Bowman, N. Leela Rau, P. Ryan Moe, Nalini Samavedy, Rif El-Mallakh, (at University of Louisville, Louisville), Husseini Manji and Debra A. Glitz (at Wayne State University, Detroit), Eric T. Meyer, Carrie Smiley, T.F., Leah Flury, Danielle M. Dick, H.J.E., grant R01 MH59545 to Indiana University, Indianapolis; J.P.R., Theodore Reich, Allison Goate, Laura Bierut, grant R01 MH059534 to Washington University, St. Louis; M.G.M., J.R.D., Dean F. MacKinnon, Francis M. Mondimore, J.B.P., P.P.Z., Dimitrios Avramopoulos, and Jennifer Payne, grant R01 MH59533 to Johns Hopkins University, Baltimore; W. Berrettini, grant R01 MH59553 to University of Pennsylvania, Philadelphia; W. Byerley and Mark Vawter, grant R01 MH60068 to University of California at Irvine, Irvine; W.C. and Raymond Crowe, grant R01 MH059548 to University of Iowa, Iowa City; Elliot Gershon, Judith Badner, F.J.M., Chunyu Liu, Alan Sanders, Maria Caserta, Steven Dinwiddie, Tu Nguyen, and Donna Harakal, grant R01 MH59535 to University of Chicago, Chicago; J.R.K. and Rebecca McKinney, grant R01 MH59567 to UCSD, San Diego; W.S., Howard M. Kravitz, Diana Marta, Annette Vaughn-Brown, and Laurie Bederow, grant R01 MH059556 to Rush University, Chicago; F.J.M., Layla Kassem, Sevilla Detera-Wadleigh, Lisa Austin, D.L.M., grant 1Z01MH002810-01 to NIMH Intramural Research Program, Bethesda. Genotyping services were provided in part by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through federal contract N01-HG-65403 from the National Institutes of Health to Johns Hopkins University. Data and biomaterials for the Columbia data set were collected and supported by NIMH grant R01 MH59602 (to M.B.) and by funds from the Columbia Genome Center and the New York State Office of Mental Health. The main contributors to the Columbia project were M.B. (principal investigator), Jean Endicott (coprincipal investigator), Jo Ellen Loth, John Nee, Richard Blumenthal, Lawrence Sharpe, Barbara Lilliston, Melissa Smith, and Kristine Trautman, all from Columbia University Department of Psychiatry, New York. A small subset of the sample was collected in Israel in collaboration with B.L. and Kyra Kanyas, from the Hadassah–Hebrew University Medical Center, Jerusalem. We are grateful to the patients and their family members, for their cooperation and support, and to the treatment facilities and other organizations that collaborated with us in identifying families. ",
year = "2005",
month = oct,
doi = "10.1086/491603",
language = "English (US)",
volume = "77",
pages = "582--595",
journal = "American journal of human genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "4",
}