TY - JOUR
T1 - Combinatorial transcription factors
AU - Wolberger, Cynthia
PY - 1998/10
Y1 - 1998/10
N2 - Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATα2/MCM1-DNA complex,the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPα/β ETS domain-ankyrin repeat heterodimer bound to DNA.
AB - Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATα2/MCM1-DNA complex,the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPα/β ETS domain-ankyrin repeat heterodimer bound to DNA.
UR - http://www.scopus.com/inward/record.url?scp=0032190610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032190610&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(98)80010-5
DO - 10.1016/S0959-437X(98)80010-5
M3 - Article
C2 - 9794820
AN - SCOPUS:0032190610
SN - 0959-437X
VL - 8
SP - 552
EP - 559
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -