Combinatorial transcription factors

Research output: Contribution to journalArticle

Abstract

Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATα2/MCM1-DNA complex,the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPα/β ETS domain-ankyrin repeat heterodimer bound to DNA.

Original languageEnglish (US)
Pages (from-to)552-559
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume8
Issue number5
DOIs
StatePublished - Oct 1998

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Transcription Factors
DNA
Proteins
Ankyrin Repeat

ASJC Scopus subject areas

  • Genetics

Cite this

Combinatorial transcription factors. / Wolberger, Cynthia.

In: Current Opinion in Genetics and Development, Vol. 8, No. 5, 10.1998, p. 552-559.

Research output: Contribution to journalArticle

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