Combinatorial transcription factors

Research output: Contribution to journalArticlepeer-review

Abstract

Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATα2/MCM1-DNA complex,the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPα/β ETS domain-ankyrin repeat heterodimer bound to DNA.

Original languageEnglish (US)
Pages (from-to)552-559
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume8
Issue number5
DOIs
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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