Combinatorial patterns of histone acetylations and methylations in the human genome

Zhibin Wang, Chongzhi Zang, Jeffrey A. Rosenfeld, Dustin E. Schones, Artem Barski, Suresh Cuddapah, Kairong Cui, Tae Young Roh, Weiqun Peng, Michael Q. Zhang, Keji Zhao

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Abstract

Histones are characterized by numerous posttranslational modifications that influence gene transcription. However, because of the lack of global distribution data in higher eukaryotic systems, the extent to which gene-specific combinatorial patterns of histone modifications exist remains to be determined. Here, we report the patterns derived from the analysis of 39 histone modifications in human CD4+ T cells. Our data indicate that a large number of patterns are associated with promoters and enhancers. In particular, we identify a common modification module consisting of 17 modifications detected at 3,286 promoters. These modifications tend to colocalize in the genome and correlate with each other at an individual nucleosome level. Genes associated with this module tend to have higher expression, and addition of more modifications to this module is associated with further increased expression. Our data suggest that these histone modifications may act cooperatively to prepare chromatin for transcriptional activation.

Original languageEnglish (US)
Pages (from-to)897-903
Number of pages7
JournalNature genetics
Volume40
Issue number7
DOIs
StatePublished - Jul 1 2008

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ASJC Scopus subject areas

  • Genetics

Cite this

Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T. Y., Peng, W., Zhang, M. Q., & Zhao, K. (2008). Combinatorial patterns of histone acetylations and methylations in the human genome. Nature genetics, 40(7), 897-903. https://doi.org/10.1038/ng.154